The journey is unlimited. Learning should be too.

Peak Human is unfettered innovation. That value is based on our lifelong belief in continuous learning. Dr. Sanjeev Goel has spent decades acquiring knowledge from the front edge of medical innovation and now shares his insights with you.

Welcome to the Learning Center.

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Health

What Is Chelation Therapy? Important Risk Factors You Need to Know

Overview Have you ever heard of chelation therapy? It’s the treatment of choice proven to treat conditions related to heavy metal toxicity. Yet, despite its effectiveness, chelation therapy is often overlooked and underappreciated. Many people falsely believe that the human body can get rid of heavy metals on its own, but the truth is that heavy metal toxicity is a serious and prevalent problem. According to the World Health Organization (WHO), millions of people worldwide are affected by heavy metal poisoning annually – a “burden of disease,” as the health agency calls heavy metal poisoning. This affliction is especially true for those regularly exposed to heavy metals, such as industrial workers and people who live near polluted areas. In 2019, lead poisoning alone was responsible for half of the 2 million lives lost due to chemicals. At the end of the day, although chelation therapy is a brilliant way to remove toxins from the body, raising awareness about this treatment is crucial so that more people can benefit from its life-changing effects. This article discusses chelation therapy, its mechanism of action, application techniques, benefits, and the risk factors you should know before starting a heavy metal detox.   Heavy Metal Detox: How Chelation Therapy Can Be an Antidote to Your Body and Mind What Is Chelation Therapy? Chelation therapy is a medical treatment involving chelating agents to remove heavy metals from the body, such as: Lead Arsenic Cadmium Thallium Mercury   Heavy metal toxicity is a severe health concern from exposure to various sources, such as contaminated air, water, food, and medical treatments. While the human body can get rid of harmful chemicals on its own, the amount removed may not be sufficient, leading to the accumulation of toxic substances in the system. Chelation therapy has been used to treat heavy metal toxicity for decades. Yet, it is also a part of treating other conditions, such as cardiovascular and neurodegenerative diseases. Despite the effectiveness of chelation therapy, many people are unaware of its benefits, and some still believe that the human body can get rid of heavy metals on its own. Unfortunately, this misconception is extremely dangerous as heavy metal toxicity still exists no matter how hard our body tries to keep itself healthy.   How Does Chelation Therapy Work? Chelation therapy uses chelating agents to remove metals from the body and restore health. Chelating agents are organic or inorganic substances that can bind to metal ions, forming a complex that can be easily eliminated from the body through the excretory system. The most common chelating agents are: EDTA (ethylenediamine-tetraacetic acid) DMSA (dimercaptosuccinic acid)   During the therapy, the chelating agent is administered into the body either intravenously (into a vein) or orally. Once inside the body, the chelating agent travels through the bloodstream, binding to heavy metals and forming a complex. This complex is then eliminated from the body primarily through urine. Chelation therapy can take several sessions, depending on the severity of the heavy metal toxicity. For example, 20 to 40 sessions are typically necessary for EDTA chelation therapy. Each session may last from 30 minutes to several hours.   Types of Chelating Agents Used in Therapy EDTA and DMSA are the two primary chelating agents used in chelation therapy. While they have similar mechanisms of action, some differences exist regarding their benefits, uses, and conditions they can treat.   EDTA Chelation Therapy EDTA is a polycarboxylic amino acid that binds to heavy metals, including lead and mercury. It is administered intravenously and can remove heavy metals from the bloodstream. Besides treating heavy metal toxicity, EDTA is effective in atherosclerosis, a condition where plaque builds up inside the arteries.   DMSA Chelation Therapy DMSA is a sulfhydryl-containing compound. DMSA’s hydrophilic nature results in significant absorption in the gastrointestinal tract, hence administered orally. It can remove mercury, cadmium, and arsenic and is often used to treat lead poisoning in children. DMSA is also used in the treatment of autism.   Which Is Better? While EDTA and DMSA are equally effective chelating agents used in various heavy metal poisoning conditions, their uses and benefits differ. EDTA is more effective at removing heavy metals from the bloodstream and is often used to treat cardiovascular conditions. Meanwhile, DMSA can also remove heavy metals from the body but must be taken shortly after exposure to avoid accumulation and toxicity. Therefore, it is crucial to consult a qualified healthcare provider to determine which chelating agent is best for each case.   How Is Chelation Therapy Applied? The procedure involves several steps, varying depending on the chelating agent used and the condition being treated. Below is a step-by-step procedure for chelation therapy: Initial consultation: The patient meets with a healthcare provider to discuss their symptoms, medical history, and previous exposure to heavy metals. Diagnosis and assessment: The healthcare provider may perform a blood test or other diagnostic tests to assess the patient’s level of heavy metal toxicity. Chelating agent administration: Depending on the specific chelating agent used, it may be administered intravenously or orally. Monitoring: The patient is closely monitored throughout the chelation therapy session, which may take 30 minutes to several hours. Repeat sessions: Depending on the severity of the heavy metal toxicity, the patient may undergo several sessions, typically once a week. Follow-up: Patients may undergo follow-up diagnostic tests after the chelation therapy sessions to assess their condition.   Proven Benefits of Chelation Therapy Heavy Metal Toxicity According to research, fundamental principles of metal poisoning treatment deal with a step-by-step methodology, which is as follows: Prevention of further metal absorption into the system Elimination of metal from the circulation Inactivation of metal bioavailable in the system   Research also indicates that metal poisoning can be acute or chronic. Symptoms of acute poisoning are often evident, recognizable, and immediately treatable. However, chronic metal toxicities may be poorly described as general illnesses and not identifiable as any conventional disease. Moreover, chronic toxicities may be irreversible, causing delayed or undetectable development of other conditions, like

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Health

How Does Dehydration Affect the Physical and Cognitive Performance of Athletes?

Overview Did you know that our bodies are 75% water? Water isn’t just a thirst quencher. It’s a life-giver. For athletes, water is their secret weapon. Why? Muscles are a crucial part that fuels an athlete’s performance. And guess how much water there is in the muscles? It’s also 75%. Not only does water help athletes perform at their peak, but it also prevents dehydration, which can seriously impact their performance. That’s why staying hydrated is vital! Meanwhile, dehydration causes a decrease in blood volume, which means less oxygen gets to the muscles. And that’s when the cramps and fatigue kick in, making it impossible for athletes to give their best performance. Not to mention the cognitive impairment dehydration can cause, resulting in confusion, irritability, and a lack of focus. This article discusses the importance of water for athletes who require regular fluid intake to compensate for their massive water loss level, explains exercise-induced dehydration, and shows how to prevent dehydration before, during, and after exercise.   Stay Hydrated, Athletes! Learn the Impact of Dehydration on Performance What Happens When We Exercise? When we exercise, our bodies undergo a series of physiological changes to meet the demands of physical activity. Our muscles require more energy, supplied by the breakdown of glucose and fats. This process increases the production of carbon dioxide (CO2) and heat, causing our body’s temperature to rise. If the body reaches its heat limit, meaning the temperature continuing to increase will cause overheating, it needs to cool off through perspiration. Sweating or perspiration is the body’s way of regulating its temperature. Sweat glands all over the body release a liquid mixture of water, salt, and electrolytes onto the skin’s surface. As the sweat evaporates, it carries away heat and lowers the body’s temperature. However, excessive sweating can cause dehydration, leading to various problems. Dehydration happens when the body loses more fluid than it consumes. This phenomenon can occur when we don’t drink enough water, especially during and after prolonged or intense exercise. Dehydration causes fatigue, muscle cramps, dizziness, and even heat stroke or heat exhaustion, which can be life-threatening.   What Does Exercise-induced Dehydration Mean? One of the most predominant targets of dehydration is athletes, who lose a massive amount of fluid due to intense physical activity. This event is called exercise-induced dehydration, typically occurring during and after training. According to the American College of Sports Medicine, a water loss of only 2% of body weight can result in dehydration, significantly affecting performance and increasing the risk of heat exhaustion or heat stroke. Exercise-induced dehydration is a common problem, with research indicating that up to 28% of Americans experience some degree of dehydration during workouts, making it a frequent cause of hospital admission. Also, a study published in the Journal of Athletic Training found that college athletes had a high prevalence of dehydration, with 20% of male and 34% of female athletes experiencing it during practice or competition. Professional athletes are particularly vulnerable to exercise-induced dehydration, as their intense training regimens and competition schedules require them to perform at their highest levels under physical stress. As a result, athletes must be aware of the risks of dehydration and take appropriate measures to prevent it. In other words, dehydration prevention strategies should be critical to every training regimen and competition schedule.   How Do You Know You Are Dehydrated? Paying attention to the signs and symptoms of dehydration is equal to preventing serious health risks. Monitoring your urine color is the easiest way to tell if you’re dehydrated. For example, dehydration occurs if your urine is dark yellow or amber-colored. Other signs and symptoms of dehydration during exercise include: Thirst: Feeling thirsty is the body’s way of telling you it needs more water. Dryness: You may experience a dry mouth and throat when dehydrated. Fatigue: Dehydration can cause fatigue, weakness, and dizziness. Headache: Dehydration can cause a headache, which may worsen with movement. Muscle cramps: Dehydration can cause muscle cramps in the legs and arms. Nausea and vomiting: Dehydration can cause nausea and vomiting, especially during intense exercise. Rapid heartbeat and breathing: When dehydrated, your heart may beat faster, and your breathing may become shallow. Dark circles under the eyes: Dehydration can cause dark circles under the eyes. Reduced urine output: Dehydration can reduce urine output, which may be darker when urinating.   How Does Dehydration Affect Performance? Physical Performance Studies have shown that even mild dehydration can lead to decreased physical performance and an increased risk of injury among athletes. A study published in the Journal of Athletic Training found that dehydration negatively impacted the performance of college athletes during practices and games. The study showed that dehydrated athletes had a higher heart rate (extra 3 to 5 beats per minute for every 1% body weight loss due to water loss), increased fatigue, lower cardiac output and arterial pressure, and lower overall performance than hydrated athletes. Another study published in Nutrition Reviews found that dehydrated endurance athletes, in the range of 2.6% to 5.6% body weight, experienced a decrease in short-duration (5 to 30 minutes) and high-intensity exercise performance. The study also discovered that, over a threshold of 3.1%, each percent loss in body weight results in a 2.9% reduction in maximal oxygen use. Moreover, a 2.3% pre-exercise body weight drop reduced time-trial running performance compared to a hydrated condition.   Cognitive Performance According to research, the severity of dehydration may influence how badly cognitive function is affected. For example, women’s mood characteristics, including vigor, alertness, tiredness, calmness, confusion, and happiness, are significantly impacted during water deprivation. Also, children drinking insufficient water may experience temporary cognitive decline. Meanwhile, increased water consumption has been linked to improved visual attentiveness and short-term memory in long-distance runners and walkers. However, the bigger problem is that only a 2% loss of a person’s body weight is enough to cause all those impairments to human cognition. For a 150-pound person, this amount corresponds to a body weight loss of 3 lbs,

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Biohacks

Understanding How Biohacking Works for Weight Loss

Overview Biohacking has increasingly become a buzzword that attracts massive attention from the medical community and general fitness enthusiasts. While this term is usually associated with technically demanding practices that can only be performed in a lab while promising little to no tangible or measurable effectiveness, the biohacking world is blooming recently with more advanced techniques that address various health aspects. As a result, those constantly looking to improve their health and achieve peak performance may greatly benefit from the incredible and science-based shortcuts to optimal well-being. From biohacking the brain for elevated cognitive functions to biohacking the waistline for healthy body composition, this practice has reached beyond a fad trend to become a genuine game-changer in upgrading the quality of life. This article discusses the most commonly accepted definition of biohacking for weight loss and management, explains how biohacking works and provides the top-of-the-line techniques of biohacking that result in the most significant benefits.   Biohacking for Weight Loss – Learn Science-backed Shortcuts to Losing Weight What Is Biohacking for Weight Loss? Despite continuous medical science and technology development in the past several decades, the foundations for weight loss and management have remained unchanged: diet, exercise, and supplementation. However, scientists and fitness experts have constantly shown their endeavor to condense the weight loss process through strategies and approaches that target the human body in a way that is unprecedented in history. One of the most prevalent examples of this unwavering attempt to manipulate weight loss is the invention of the Vasper biohack technology by Vasper Systems. This fitness device claims that users can reap the benefits of 2 hours of intense exercise in only 21 minutes of low-intensity exercise. While this result seems too good to be true, the Vasper technology is a product of combined science and technology. Surprisingly, the secret behind the scene is nothing more than compression, circulation, and cooling; all together at once. That is to say, biohacking for weight loss, in the most accurate definition, is the practice of inducing weight loss in a non-traditional way by addressing the usually ignored aspects of human health regarding weight loss, such as hormones or metabolism. Traditionally, whether weight loss comes down to being successful or not is associated with how many calories a person burns or how much food is consumed. However, what if we can still induce weight loss effectively while taking away all or most of the work that is usually the cause of failing adherence or sustainability? The Vasper technology mentioned above shortens the duration of a workout by almost 6 times, from 120 to just 21 minutes, which can offer a mighty leap toward sustainable weight loss.   Losing weight using the Vasper technology can be a game-changer to biohack weight loss – Source: Channel 4 Entertainment.   How Does Biohacking for Weight Loss Work? Until now, there has been no limitation regarding the mechanism of actions of biohacking for weight loss. It is because each method considered biohacking works differently, and therefore, giving an all-in-one formula for biohacking appears infeasible. For example, the Vasper technology leverages the combination of compression on the major muscle groups in the body, circulation of the endocrine system, and cooling for oxygenation and recovery to result in peak performance at the expense of little effort. Another similar biohacking approach is the implantation of microchips into the body to track diet and sleep patterns. Given that how we eat and sleep tremendously affect weight loss, it makes sense when someone puts every body activity into a measurement. Biohacking for weight loss also involves optimizing your diet by focusing on nutrient-dense, whole foods low in sugar and processed carbs. This optimization can help regulate blood sugar levels, reduce inflammation, and promote weight loss. Also, eating balanced macronutrients, including carbohydrates, protein, and fat, can help regulate hormones, reduce cravings, and promote weight loss. Many may ignore the importance of hormones in weight loss. The truth is the other way around. Hormones are essential because they regulate various processes in the body that can impact your ability to lose weight. For example, when you eat carbs, your body releases insulin to move glucose away from your blood. High insulin levels can lead to insulin resistance, contributing to weight gain and other health issues.   Benefits of Biohacking for Weight Loss Less Effort, More Benefits You can benefit from whatever techniques and strategies you are implementing, like diet, exercise, and supplementation, while making the weight loss process simpler and more manageable with biohacking. By utilizing cutting-edge technology, biohacking can help individuals reach their weight loss goals faster and more efficiently than traditional methods. In addition, biohacking can eliminate the need for strenuous exercise routines or restrictive diets, making it easier for individuals to incorporate weight loss practices into their daily lives. So by taking advantage of the benefits of biohacking, you can achieve your weight loss goals without sacrificing your time, energy, or enjoyment of life.   Take Body Under Control Biohacking for weight loss also allows you to manipulate your fitness journey and goals by understanding your body’s unique needs and characteristics. With technology and data-driven approaches, biohacking can also help you identify the underlying factors contributing to your weight gain and tailor your weight loss strategies accordingly. This approach can help you identify what works for your body and what does not, allowing you to make informed decisions about your health at the right time. For example, suppose you constantly measure your blood sugar levels and notice that they always spike after a meal. In that case, it is the right time to reduce the sugar and carbs portion. Remember that high blood sugar and insulin do not manifest on the surface of your body, and using specific tools to track and analyze is the only way to have such information.   Biohacking Techniques for Weight Loss Intermittent Fasting and Fasted Exercise Intermittent fasting and fasted exercise are two popular biohacking techniques for weight loss that can help

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Health

Metabolic Benefits of Exercise: How Building Muscle Can Help You Burn More Calories

Overview When it comes to the topic of weight loss, most people tend to fixate on shedding excess fat rather than focusing on building muscle. We yearn for leaner bodies, envisioning a future where fat stores vanish and we emerge with a slender physique. However, it’s time to unveil the truth: we tend to be under-muscled rather than over-fat. In our quest for weight management, we often overlook the role of muscle mass in our metabolic health. Building muscle enhances strength and physical performance and ignites a cascade of metabolic benefits. Therefore, increasing our muscle mass can boost our body’s ability to burn fat and maintain a healthy weight. In this article, we delve into the remarkable metabolic benefits of exercise and shed light on its profound impact on our overall metabolism. We’ll also explore how building muscle is the key to increased calorie burn and achieving long-term weight management success.   Fueling Your Calorie-burning Engine: Exploring the Metabolic Benefits of Exercise The Science Behind Calorie Burning Understanding Basal Metabolic Rate (BMR) Contrary to a widespread misconception, the total calorie intake does not solely determine the energy a person needs to burn to maintain a calorie balance. Even at rest, our bodies continue to burn many calories. This energy expenditure is known as Basal Metabolic Rate (BMR) or Resting Metabolic Rate (RMR) and can contribute to at least 60% of our total calorie expenditure (TEE). Surprisingly, physical activities only account for around 30% of TEE. In comparison, the remaining 10% is allocated to the energy required for digestion and absorption of food, a process referred to as diet-induced thermogenesis. Understanding the significance of BMR/RMR sheds light on how our bodies constantly utilize energy, even during rest periods. This basal metabolic activity is essential for maintaining vital bodily functions such as breathing (5-10% of TEE), circulating blood (3-4%), regulating body temperature (5-10%), and supporting organ function (20-25%).   Exercise and Total Energy Expenditure (TEE) Although we naturally burn a significant amount of energy as BMR/RMR, many individuals consume more calories than they need, especially when regular exercise is absent. This discrepancy from the ideal scenario where calorie intake matches BMR/RMR without physical activity can be attributed to various factors. Oversized portions, prevalent in packaged foods, contribute to consuming more calories per meal. The abundance of high-calorie foods, often rich in added sugars, unhealthy fats, and refined carbohydrates, can be irresistible, leading to overconsumption. Emotional eating and food cravings further disrupt calorie balance as individuals use food as a coping mechanism. Mindless eating, distractions while eating, social influences, and a lack of awareness regarding calorie content also contribute to excess calorie intake. By incorporating exercise into daily routines, individuals can strive for a balance of energy, ensuring that calories in and out are aligned. This alignment determines whether a person can match their total calorie expenditure (TEE) with their daily calorie intake.   The Role of Muscle in Calorie Burning Muscle and Fat: Energy Metabolism Differences Muscle and fat tissues differ in energy metabolism, with muscle being more metabolically active than fat. As a result, even at rest, muscle burns more calories than fat. One pound of fat burns roughly 2 calories per hour, while one pound of muscle burns 6 calories per hour. This discrepancy means that over 24 hours, one pound of muscle can burn around 96 more calories than one pound of fat. This higher energy demand is because muscles are involved in various activities regarding the overall body functioning. Meanwhile, fat and muscle have different densities. So one pound of fat takes up more space in the body than one pound of muscle.   Afterburn Effect and Additional Calorie Burn Muscles also play a role in a phenomenon known as the “afterburn effect,” or excess post-exercise oxygen consumption (EPOC). After exercise, the body continues to consume oxygen at an elevated rate to restore various physiological processes to their pre-exercise state. This recovery period can last from a few minutes to several hours, depending on the intensity and duration of the exercise. During the afterburn effect, muscles require additional energy to repair damaged tissues, replenish depleted glycogen stores (an immediate supply of glucose for muscle cells), remove metabolic byproducts such as lactate (also known as lactic acid, which causes muscle fatigue and soreness when builds up), and restore oxygen levels. The EPOC effect contributes to additional calorie burn (6-15% of an exercise) because the body taps into stored energy sources, primarily fat, to meet the increased metabolic demands during recovery. The higher the intensity and duration of the exercise, the more pronounced the EPOC effect and subsequent calorie burn.   Building Muscle: The Key to Increasing Calorie Burn One way to build muscle is through resistance training, which involves performing exercises against resistance, such as resistance bands. Resistance training not only strengthens existing muscle fibers but also stimulates the growth of new muscle tissue. Another approach to building muscle is through muscle-building exercises specifically targeting muscle hypertrophy. These exercises typically involve higher repetitions and moderate to heavy weights, focusing on specific muscle groups. Examples include squats, lunges, bench presses, and bicep curls. Incorporating these exercises into a comprehensive strength training program helps stimulate muscle growth, boost calorie burn, and improve overall body composition. To engage in resistance training: Start by selecting appropriate exercises that target major muscle groups. Perform 2-3 sets of 8-12 repetitions with a weight that challenges you while maintaining proper form. Gradually increase the weight as you become stronger. For muscle-building exercises, aim for higher repetitions (10-15) and focus on feeling the target muscle group working. Use weights that provide sufficient resistance without sacrificing proper technique. Prioritize rest and recovery to allow muscles to repair and grow stronger.   Muscle Vs. Cardio: Which for Calorie Burning The debate between muscle-focused exercises (strength training) and cardio exercises (aerobic exercises) often arises regarding calorie burning. However, both types of exercise have unique benefits for metabolism and calorie expenditure. Cardio exercises like running, cycling, or swimming are known

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Health

The Neuroscience Behind Meditation

Overview Throughout history, it’s reported that people have been practicing meditation for longer than anticipated, and it has received increasing attention from East to West. Today, more than a powerful tool to pursue conscious living and promote general well-being, the meditative practice using breathing techniques to foster relaxation has captured most attention from neuroscientists for its remarkable impacts on overall cognitive functions, such as memory, attention, cognitive flexibility, and executive function, based on the sole belief that the brain is not hardwired once we reach adulthood, but constantly remains adaptive and open to alterations and adjustments when learning or developing new skills. This discovery has led to further research emphasizing the benefits of meditation on the brain, implying that we can train and exercise our brain to mitigate the aftermath of aging that comes with increasing age. What is the neuroscience behind meditation, and how can we proactively take control of our brain to keep it active and healthy with time? Let’s go over the neuroscience of meditation and explore the potential benefits of meditation for overall cognitive wellness and abilities.   What Does Neuroscience Have to Say About the Impact of Meditation on the Brain? What Is Meditation? The definition of meditation is relatively vague and can vastly vary in different cultures. In simple terms, meditation is a well-known technique that encourages body-mind integration and mental focus with the utilization of deep breathwork or a repetition of a word or phrase. For millennia, in different cultures all around the world, people have used meditation to exercise their brains, engage with their inner thoughts, and refocus their attention. Many believe meditation was originally a cornerstone of spiritual development in many major world religions, such as Buddhism, Christianity, Hinduism, and Islam. Despite the varying techniques, the orientation of meditation in each religious setting was all about tuning in mental awareness, cultivating calmness, and enhancing well-being. Today, the primary purpose of meditation is based on better understanding one’s self and surroundings when enthusiastic meditators are accustomed to the centuries-old practice to harness a sense of relaxation, enhance overall wellness, and gain insight into the meaning of life. Meditation is simple, and anyone can practice it without workout gear or attires needed. The meditative practice has also captured a great deal of attention from the public as effective stress management, with numerous studies praising meditation for its extensive abilities in warding off stress, relieving associated symptoms and discomfort, and resolving conflicts amid hectic lifestyles and schedules. Meditation is divided into nine types of practice, with each affecting the meditator differently depending on their needs and preferences: Mindfulness meditation Spiritual meditation Movement meditation Focused meditation Transcendental meditation Mantra meditation Progressive relaxation Visualization meditation Loving-kindness meditation   What Is Neuroscience? Neuroscience was developed to obtain more knowledge about the human brain. It encompasses the exploration of the brain and the nervous systems, as well as all aspects of the brain’s activities, from formation, development, and structure to functions, malfunctions, and alterations. To map out the brain network, neuroscientists utilize various methodologies to examine and investigate the brain’s overall behaviors and cognitions at a mechanistic level. The brain network, or neural circuits, is responsible for the brain’s diverse functionalities and processes all responses of the human body when activated. The neural network signals different brain regions to carry specific functions after the auditory and conversion of neural messages through the interconnected network of synapses.   Understanding the Brain In addition to being a vital organ, the brain is an incredibly complex system as it houses approximately 80 to 100 trillion neurons despite only accounting for 2-3% of the body weight. These millions and millions of ever-growing brain cells stack and intertwine with others, creating a cell-to-cell communication network. In light of advanced medicine and the more we learn about the brain and its trivial activities, a slew of evidence has confirmed that, unlike other body parts, the brain never stops developing. It means it continues to evolve and adapt to changes or alterations until death, with learning or practicing a new set of skills further proving the brain’s ongoing development into adulthood. Every time we learn new skills, the brain regions accounting for particular activities form new neurons, connections, and patterns from repeated engagements. In other words, our brains become bigger when learning something new, like muscle training. Conversely, the brain is prone to shrinkage over time when we stop exercising our brain, accompanied by other factors like pollutants, substance abuse, and intrinsic aging. This logically explains why the more adults age, the more they are encouraged to keep their brains active with brain-stimulating activities into their golden years, as it is reported that our brains shrink at faster rates than the rates of neuron production as soon as we turn 40, leading to rapid brain decline into the age of 50 and beyond. However, maintaining mental sharpness should be a daily habit that starts as early as possible, regardless of age. There are many ways to promote brain health and protect it from the ultimate consequences of aging, such as getting up and moving, playing brain games, picking up new hobbies or habits, playing instruments, and learning new languages. And meditation is considered one of many activities that could help with brain health and development.   Meditation & the Brain: What Does Neuroscience Say? Before the establishment of neuroscience and neurobiology, the mechanism behind the vital organ remained a lifelong mystery. Therefore, it was mostly, if not completely impossible, to learn more about the effects of meditation on the brain, even though many meditators have sworn by the impressive benefits of meditating on their overall health for decades. In recent years, the benefits of meditation have intrigued neuroscientists, leading to the ongoing rollout of many research studies on the interplay between meditation and the brain. Following these studies producing tremendous outcomes in the last few years, it’s been shown that meditation can provide immeasurable benefits for the brain. What actually happens to the brain

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Diet

Ketogenic Diet, Alternated Weekly With a Normal Diet, Can Increase Healthspan and Memory

Overview The ketogenic diet has been making waves in both the general population and the scientific community in recent years, thanks to its potential benefits for various aspects of health. This dietary approach, commonly called the keto diet, has gained popularity primarily for its association with weight loss and the potential prevention of chronic diseases. However, the diet also faces its fair share of controversy, with critics arguing that increasing fat intake and losing body weight can be achieved simultaneously, casting doubt on the validity of the ketogenic diet as a sustainable and evidence-based eating pattern. Amidst the ongoing debate, it becomes crucial to delve into the latest research surrounding the keto diet and its impact on health to separate fact from fiction. This article provides a comprehensive review of the current scientific knowledge on the ketogenic diet, addressing its pros and cons and shedding light on its possible health outcomes. The article primarily refers to the 2017 Cell Metabolism publication by John C. Newman et al.: Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.   Cyclic Ketogenic Diet Reduces Midlife Mortality and Preserves Memory in Mice Ketogenic Diet: Definition, Mechanisms, and Benefits What Is a Ketogenic Diet? A ketogenic diet is a dietary approach that focuses on triggering a metabolic state called ketosis. In this state, the body shifts from using glucose (derived from carbohydrates) as its primary energy source to burning fat for fuel. A high-fat, low-carbohydrate, and moderate-protein intake characterizes the keto diet. The macronutrient composition of a keto diet consists of 70% fat, 10% carbohydrates, and 20% protein. As a result, the body is prompted to enter ketosis by significantly reducing carbohydrate intake, leading to a shift in metabolic processes.   How Does Ketogenic Diet Work? The low carbohydrate intake in a ketogenic diet restricts the availability of glucose, the preferred energy source for the body. As a result, the body starts breaking down stored fats into molecules called ketones through ketogenesis. Ketones, such as beta-hydroxybutyrate (BHB), serve as an alternative fuel source for various tissues, including the brain. This metabolic adaptation allows the body to utilize stored fat for energy production, leading to weight loss and other health benefits. The controversy is, does increasing fat intake in the ketogenic diet (70%) increase body fat before causing the body to burn stored fat as energy? No, increasing fat intake does not inherently lead to increased body fat. Instead, on a well-formulated ketogenic diet, implemented every other week and not continuously, high fat intake provides satiety, promotes stable blood sugar levels, and helps sustain energy levels. At the same time, the body efficiently burns stored fat for fuel.   Ketogenic Diet Benefits Weight loss: The ketogenic diet has been associated with significant weight loss, primarily due to increased fat-burning and reduced appetite. Improved insulin sensitivity: By limiting carbohydrate intake, the ketogenic diet can help stabilize blood sugar levels and improve insulin sensitivity, benefiting people with diabetes or metabolic syndrome. Enhanced mental clarity and focus: Ketones are an efficient energy source for the brain, which may result in improved cognitive function and mental clarity. Reduced inflammation: Some research suggests that the ketogenic diet may reduce inflammation in the body, which is associated with various chronic diseases. Potential seizure control: The ketogenic diet has been a therapeutic approach for reducing seizures in individuals with epilepsy, particularly children. Potential cardiovascular benefits: A ketogenic diet may improve cardiovascular factors, such as triglyceride levels, blood pressure, and cholesterol. Potential benefits for neurological conditions: The ketogenic diet is under investigation for its potential benefits in various conditions such as Alzheimer’s disease, Parkinson’s disease, and neuronal injury.   Ketogenic Diet: Why Alternate-week and Not Continuous The Continuous Ketogenic Diet Is Obesogenic Research by John C. Newman et al. has shed light on the obesogenic effects of a continuous ketogenic diet and, in turn, discovered the most optimal pattern. Their study involving mice showed that mice fed a ketogenic diet continuously from 12 to 36 months of age experienced a significant increase in body weight, reaching up to 70% higher compared to those fed a standard diet before reaching the 24-month mark. While these continuously ketogenic diet-fed mice eventually reduced their weight to a greater extent than their counterparts on a standard diet before reaching the end of their lifespan at 36 months, they exhibited a greater tendency towards obesity during midlife.     The Continuous Ketogenic Diet Affects Healthspan The study highlighted that mice continuously fed a ketogenic diet displayed a slightly shorter lifespan. Survival rate analysis also revealed a notable decline in health span, with the most significant drop occurring before the mice reached three-quarters of their maximum age. These findings suggest prolonged adherence to a ketogenic diet may adversely affect overall health and longevity.   The Cyclic Ketogenic Diet: A Non-obesogenic Diet In contrast to the continuous ketogenic diet, a cyclic ketogenic diet offers distinct advantages, alternating between periods of ketogenic and standard diet. Mice following a cyclic ketogenic diet maintained similar health characteristics to those on a standard diet, including body weight and lifespan. Moreover, this diet demonstrated additional benefits, such as improved metabolic flexibility and cognitive function. Notably, the cyclic ketogenic diet was non-obesogenic, as it allowed sufficient time for metabolic adaptation and prevented the development of obesity in the mice.   Ketogenic Diet Improves Midlife Survival But Not Lifespan The research findings by John C. Newman et al. suggest that a cyclic ketogenic diet (Cyclic KD; 10% protein and 90% fat; fat content: 24% saturated, 39% monounsaturated, and 37% polyunsaturated) improves midlife survival. However, it does not extend the overall lifespan compared to a control (10% protein, 13% fat, and 77% carbohydrates) diet. Mice on Cyclic KD showed similar body weight to the control group, while mice on a cyclic high-fat diet (Cyclic HF; 10% protein, 75% fat, 15% carbohydrates) were slightly heavier. Caloric intake was higher during KD or HF diet weeks and lower during control diet weeks for both groups. Cyclic KD and

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Uncategorized

The Brain-gut Connection: Link Between Diet and Mental Health

Overview In recent years, there has been a growing interest in the role of nutrition in preventing and treating various diseases. However, using nutrients as a primary therapy for many illnesses is still relatively new. As a result, we often overlook the importance of a balanced and nutrient-rich diet in maintaining our physical and mental well-being. “We are what we eat.” Indeed, what we consume can significantly impact our overall health, and a lack of vital nutrients can lead to severe consequences, including mental health problems. In addition, the brain-gut connection highlights the intricate relationship between the gut and the brain and how it affects human psychology. This article explores the importance of nutrients and diet in mental health and how they can help prevent, treat, and manage mental disorders.   Humans Have a “Second Brain” That Communicates With and Controls the Mind The Brain-gut Connection The brain-gut connection refers to the complex bidirectional communication network between the brain and the gut. Scientists have suggested that the role of the gut in controlling human behavior is equally significant as the brain in our heads. Hence, the gut is often considered the body’s “second brain.” And there is a good reason for this recognition. Looking inside your belly, you’ll discover that the gut is home to trillions of microorganisms collectively known as the gut microbiome. This vast army of microbes and the brain communicate through the gut-brain axis (GBA), which is composed of the central nervous system (CNS), the enteric nervous system (ENS), and the endocrine system. Because the gut microbiome is crucial in regulating the gut-brain axis, it’s also vital to mental health. But how so, exactly? The gut microbiome influences brain behavior by producing neurotransmitters and hormones that affect mood, cognition, and emotions. For example, gut bacteria produce 95% of total body serotonin, a neurotransmitter that regulates sleep. Also, they’re involved in producing gamma-aminobutyric acid (GABA), a regulator of anxiety and stress. The gut microbiome also produces short-chain fatty acids (SCFAs) through the fermentation of dietary fiber, which has anti-inflammatory properties and can have a far-reaching effect on the CNS. Conversely, stress and emotional disturbances can impact the gut microbiome by altering its composition and function in producing crucial compounds.   Nutrients That Boost Mental Health Macronutrients Macronutrients such as protein, carbohydrates, and fats are the foundation for physical health. Yet, little do we know they’re also essential for a good mentality. Protein and amino acids (molecules that form proteins), such as tryptophan, are crucial for synthesizing neurotransmitters and neuromodulators. Thus, protein-rich foods can boost mental health by providing the necessary building blocks. Meanwhile, carbohydrates, particularly complex carbohydrates such as whole grains and vegetables, provide glucose, the brain’s primary energy source. Adequate glucose levels are essential for good cognitive function and mood regulation. Finally, fats, particularly omega-3 fatty acids found in fatty fish and nuts, are crucial for brain health and the maintenance of cell membranes. In addition, omega-3 fatty acids have been shown to improve mood and reduce symptoms of depression and anxiety.   Micronutrients Micronutrients, such as vitamins and minerals, are also crucial in maintaining good physical and mental health. In particular, some vitamins and minerals have been linked to positive health outcomes in patients with mental disorders. For example, studies have shown that vitamin D deficiency is associated with depression, while supplementation with vitamin D can improve mood. Meanwhile, B vitamins, particularly B6, B9, and B12, are essential for neurotransmitter synthesis and have been linked to a reduced risk of depression and improved cognitive function. Minerals such as iron, zinc, and magnesium also affect mental health. For example, iron is crucial for oxygen transport in the brain and cognitive function, while zinc and magnesium have been linked to improvements in depression and anxiety.   Foods That Negatively Affect Mental Health As people say: “Where there is good, there is bad.” Sadly, this is true in everything. While there are good foods to help with mental health, bad foods also get in the way and cause dreadful troubles for the brain-gut connection. Processed foods, such as fast food, chips, and sweets, are often high in sugar, salt, and unhealthy fats. Consuming a diet high in these foods can lead to weight gain, inflammation, and oxidative stress, negatively impacting mental health. Meanwhile, sugar and unhealthy fats can disrupt the gut microbiome, leading to dysbiosis linked to depression, anxiety, and other mental health disorders. Consuming high amounts of caffeine in coffee, tea, and energy drinks can also lead to increased anxiety, jitteriness, and disrupted sleep, negatively impacting mental health. Alcohol is another beverage that can negatively impact mental health. If consumed in excess amounts, alcohol becomes a depressant that can disrupt the balance of neurotransmitters in the brain, leading to changes in mood and behavior. Other foods and beverages that can impair your mental health are: Refined carbohydrates, such as white bread and pasta Saturated and trans fats, such as fried foods and fatty meats Artificial additives, such as preservatives and food dyes Sodium, such as processed meats and canned foods   Medical Nutrition Therapy for Mental Health Medical nutrition therapy (MNT) is an emerging approach to preventing, treating, and managing mental health disorders. It is tailored to each individual’s needs to develop a nutrition plan and reinforce the brain-gut connection. Nutrition through diet is a fundamental component of good mental health. Yet, it can sometimes be insufficient in quality. How so? While it may be simple for most people to include enough foods (nutrient quantity) beneficial to the gut, only some manage to include enough types of foods (nutrient quality) providing unique nutrients that cannot be found in other foods. For example, seafood is an excellent source of omega-3 fatty acids. While some plant-based sources, such as chia seeds and flaxseeds, also contain omega-3s, they do not provide the same type of omega-3s found in seafood. Unfortunately, food variation does matter. Research has shown people must consume 30 types of vegetables, fruits, nuts, and seeds per week

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Biohacks

Biohacking Your Gut Microbiome for Weight Loss

Overview Throughout history, humans have acquainted bacteria with a bad reputation, leading us to these critters by overcooking everything, relying heavily on antibiotics for infections, and slathering our hands and bodies with antibacterial soaps. However, not all bacteria pose a threat. While some are the reasons behind infections and deadly diseases, others are relatively harmless and provide valuable support in achieving robust health and longevity. When building a leaner physique, most people are familiar with the traditional approach of counting calories, assuming that cutting back on food intake can help them lose weight more quickly. However, in the biohacking era, the weight loss approach has evolved beyond simply being in a caloric deficit and spending countless hours on the treadmill. Instead, people are shifting their attention to other factors influencing weight, such as hormonal changes, stress levels, and gut health. Specifically, many believe that making improvements, optimizing the gut microbiome, and transforming the gut microbiome can yield significant outcomes in weight management and promote faster weight loss.   Everything You Need to Know About Biohacking Weight Loss Gut Microbiome 101: How Does It Affect and Benefit Humans? When considering vital organs and systems of the human body, the brain, heart, liver, kidneys, lungs, immune system, and nervous system typically come to most people’s minds. After all, they are essential for maintaining bodily functions and protecting the body from illnesses. However, the gut system also ensures the human body’s smooth operation. When thinking of the gut, people envision a system consisting of gastrointestinal tracts and a set of connecting digestive organs, such as the pancreas, gallbladder, and liver, with the primary purpose being delivering absorbed nutrients to every tissue through the circulatory system after breaking down food into energy. However, most people often fail to recognize that the gut system is the most intricate system within the human body. It is home to roughly trillions of collective microbes. The gut system is a natural bacterial ecosystem where all tiny living organisms coexist, interact, and serve as a powerful barrier to ward off pathogens. Over the years, scientists and health experts have rolled out a handful of studies emphasizing the role of the gut microbiome in human health and its association with better health outcomes when we take good care of our gut health. The gut microbiome controls digestion, protects the body from pathogenic invasion, stabilizes our mood, communicates with other organs, balances weight, modulates the immune system, etc. Among various links found between the gut and other vital bodily processes, the gut-brain connection is the topic that has drawn a great deal of attention over the years. For example, notice how you may develop nausea when about to do something important, such as giving a presentation. Conversely, you could experience cramps or changes in bowel movements when under lots of stress.   How Are Gut Microbiome and Weight Connected? Is there a connection between the gut microbiome and weight? While the intertwined relationship between gut and brain is widely researched, with noticeable results demonstrating that stabilizing the activity of microbes inside the gut can invigorate brain health, scientists are now beginning to dig deeper into the gut-weight concept and the role of the gut microbiome in maintaining a healthy weight. A twin study has shown that obese individuals often have fewer microbes in their guts than individuals of moderate weight and leaner build. In another study where researchers looked deeper into participants’ gut bacteria composition and the amount of weight lost following a calorie-controlled diet, people with more Prevotella bacteria experienced more manageable weight and fat loss than people with more Bacteroids. It was also discovered that one participant from the Prevotella group had lower insulin levels, one of the major preconditions for a lower risk of obesity. Following the study outcome, scientists have hypothetically proposed that striking a perfect balance between good and bad bacteria can improve metabolic health as a whole and increase the chance of weight loss. In the past, most people associated weight loss with calorie restriction and physical activity. While these conventional weight loss practices work for some people, it is not always the case for others, especially if they have a genetically slow metabolism or health conditions that make it harder to lose weight. In recent years, scientists and researchers have discovered numerous pieces of evidence implying that a healthy gut microbiome can help people shed unwanted pounds. This is supported by many studies that reveal a significantly different composition of gut bacteria in lean and obese individuals.   Biohacking Weight Loss: How Can Prebiotics and Probiotics Help? You may have heard of probiotics’ impressive benefits in improving gut health. Probiotics are living microorganisms found in fermented foods and dietary supplements that can be consumed orally. After making it down to your colon, these probiotics often join forces with existing friendly microbes to sustain the bacterial balance and strengthen the gut. Prebiotics are a type of fiber that humans can’t digest. Instead, they function as a source of energy for living gut microbiota. The health benefits of prebiotics include increasing the number of good bacteria, decreasing the number of harmful bacteria, regulating bowel movements, producing neurotransmitters between the brain and the gut to trigger vital processes, aiding your bone to absorb calcium better, enhancing the body’s anti-inflammatory response, etc. Considering the crucial role of gut microbes in weight management, eating balanced amounts of prebiotics and probiotics in your everyday meals can make a difference in weight loss. In addition to shedding weight, a healthy diet rich in fibers, nutrients, and probiotics combined with a regular exercise routine also assists in positively changing the gut microbiome and enhancing the function of gut microbiota.   Tips for Biohacking Weight Loss What is biohacking? In recent years, the concept of biohacking the body for optimal health and performance has attracted much attention from health-conscious individuals. In contrast to traditional health maintenance and medicines, biohackers utilize strategic interventions, such as do-it-yourself biology, nutrigenomics, or grinder, to make steady,

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Aging

Epigenetic Factors That Influence Longevity

Overview Did you know that the number of individuals aged 90 years and older in the United States is expected to quadruple from 1.9 million in 2016 to 7.6 million in 2050? This demographic shift highlights the urgent need to advance geriatric medicine and to focus on maintaining physical and mental well-being in older age. One of the hallmarks of aging is epigenetic alterations that regulate gene expression, leading to changes in cellular function and tissue homeostasis. As such, epigenetics has gained increasing attention in longevity medicine as a biomarker of aging. This article reviews the latest findings on epigenetics and longevity to elucidate the mechanisms underlying epigenetic alterations and their effects on human lifespan. We also highlight the current progress in developing novel interventions for promoting healthy aging.   Epigenetics and Longevity: How Epigenomes Determine Our Lifespan Aging Is Not Natural but a Medical Condition Aging is a complex and multifaceted process that has been the subject of scientific inquiry for many years. Historically, aging has been viewed as a natural process that occurs in all living organisms, leading to the decline of physiological functions over time. However, recent scientific evidence suggests that aging is not simply a natural process but a medical condition that can be addressed and potentially reversed. At the cellular level, aging is accompanied by physiological changes that occur over time, including DNA damage, telomere shortening, mitochondrial dysfunction, and a decline in stem cell function. Because these changes contribute to various age-related diseases, reversing them may provide a new avenue to delay aging.   What Is Epigenetics, and Why Is It Important? Epigenetics refers to changes in gene expression (the process through which a gene’s encoded information is converted into a function) that are not caused by alterations in the DNA sequence but rather by modifications to the surrounding chemical structure. In simple terms, epigenetics is like a light switch that can turn genes on or off without changing the DNA sequence, just like how a light switch can turn on or off a light bulb without changing the wiring in the house, but it changes how the house looks. During development, epigenetics control which genes are turned on or off in stem cells, determining the cell’s fate or what type of tissue it will become. For example, a muscle cell has different epigenetics than a nerve cell, allowing it to perform its specific function. In aging, epigenetics have been associated with changes in DNA methylation and histone modifications, observed in various age-related diseases. Therefore, developing interventions that manipulate these epigenetic patterns may allow us to improve our lifespan.   Epigenetic Alterations: A Hallmark of Aging Epigenetics exist because our epigenomes can change as we age due to various reasons, such as environmental or dietary factors, causing changes in gene expression that may eventually impair cellular function and tissue homeostasis. Due to its impact on human health, epigenetic alterations have been considered one of the hallmarks of aging that act in concert with other aging factors, contributing to the decline of organismal functions and the development of age-related diseases. For example, epigenetic alterations in the brain can contribute to neurodegenerative diseases such as Alzheimer’s. In contrast, epigenetic alterations in immune cells can lead to an impaired immune system and increased susceptibility to infection and cancer.   How Epigenetic Alterations Affect Longevity Influence Stem Cell Functions A stem cell is a type of cell that can develop into many different types of cells in the body. They can divide and renew themselves to create more stem cells or differentiate into specialized cells, such as muscle cells, nerve cells, or blood cells. Epigenetic alterations can significantly impact stem cell functions, which is detrimental to maintaining tissue homeostasis and repairing damaged cells. Also, these epigenetic alterations can lead to changes in the expression of genes involved in stem cell differentiation, proliferation, and self-renewal, ultimately exacerbating tissue regeneration and contributing to the development of various diseases.   Modify Telomere Length Telomeres are the repetitive DNA sequences located at the end of chromosomes that protect the integrity of the genetic material during cell division. Telomeres shorten in length after each cell division. When they reach a critical length, the cell enters senescence or programmed cell death. Shortened telomere length has been associated with aging and age-related diseases, such as cardiovascular disease, diabetes, and cancer. Therefore, telomere length is a determinant of cellular lifespan, and its maintenance is crucial for an organism’s longevity. Epigenetic alterations can modify the expression of genes involved in telomere maintenance, leading to telomere length and function changes. For example, epigenetic alterations can affect telomerase – the enzyme responsible for maintaining telomere length. Epigenetic alterations can also affect the expression of genes that protect telomeres from degradation and retain their structural integrity.   Elevate DNA Methylation Epigenetic alterations can modulate DNA methylation, a chemical modification of DNA that can affect gene expression without changing the DNA sequence. Elevated DNA methylation levels have been associated with aging and age-related diseases. For example, DNA methylation of the tumor suppressor gene can increase with age, leading to a decline in regenerative ability and increased susceptibility to cancer. Epigenetic alterations that elevate DNA methylation levels may also affect other cellular processes, such as mitochondrial function and inflammation. For instance, DNA methylation changes in genes involved in mitochondrial function may contribute to mitochondrial dysfunction, leading to increased oxidative stress and cellular damage. Meanwhile, DNA methylation can cause inflammation to become chronic, a risk factor for various age-related diseases.   Cause Histone Modifications Epigenetic alterations can also cause histone modifications, which can affect chromatin structure and the accessibility of DNA to transcriptional machinery. Histone modifications, such as acetylation, have been linked to unhealthy aging. For example, decreased histone acetylation levels have been associated with a decline in gene expression and cellular function. Moreover, histone modifications can influence the expression of genes involved in inflammation, oxidative stress, and apoptosis, all contributing to aging. For instance, changes in histone modifications can affect the expression

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Diet

How Healthy Muscles Can Become the Foundation of Longevity

Overview Muscles are the unsung heroes of human health. At 30 – 40% of an adult’s body mass, our muscles support our body and are our largest organs. Muscles do so much for us, from helping us move around to supporting our bone health, regulating our metabolism, and even reducing inflammation. But, when it comes to achieving longevity, people tend to forget the importance of muscles. Is it time to give these incredible tissues the appreciation they deserve? This article reviews the role of these vital organs in the human body. We explain how they affect many other body components, including body fat, and how muscle and longevity have a close yet little-known connection. Also, learn to incorporate exercise and nutrition to preserve muscle mass and add more years to life.   Healthy Muscles Matter: Learn How Having Strong Muscles Is Key to Longevity The Muscle Is a Secretory Organ Muscles have long been known for their role in movement and locomotion. Still, research has revealed that they are also secretory organs that play a vital role in regulating essential hormones in the human body. Specifically, muscle tissue can produce and secrete various hormones and cytokines, which can have far-reaching effects on physiological processes, including metabolism, immune, and cognitive functions. For example, myokines are a type of hormone produced by muscles during exercise. These myokines can improve insulin sensitivity, inflammation, and brain function. Meanwhile, the hormone irisin can stimulate the browning of white adipose tissue (white fat). White fat is the depot for excess energy intake and is known to increase the risk of obesity, diabetes, and cardiovascular disease. However, suppose white fat is turned into brown fat, another type of fat tissue in the human body. In that case, it can help regulate energy metabolism and reduce the risk of obesity and related diseases.   Does Muscle Affect Body Fat? It is a common misconception that people must burn more fat to balance the proportion between fat and muscle. However, we are more under-muscled than over-fat. In other words, choose to be muscular whenever it comes to bulking and cutting. The first reason is that muscle is crucial in burning fat efficiently. The more muscular a person is, the higher their resting metabolic rate (RMR), meaning their body will burn more calories even when at rest. To explain this phenomenon: muscle tissue is metabolically more active than fat tissue, requiring more energy. So people with more muscle have a higher RMR, and their bodies need more calories to sustain that muscle tissue. Another reason to become more muscular is that when a person engages in physical activity, the body uses stored fat to fuel the muscles. Therefore, building more muscle can simultaneously lead to more efficient burning of stored fat. Resistance training is one of the most effective ways for this double effect. It forces the muscles to work against external resistance to increase strength, muscle growth, and endurance. As a person becomes more robust and muscular, their RMR increases, which means they burn more calories at rest and, therefore, more body fat.   Muscle and Longevity: The Connection Muscles Maintain Mobility and Reduce Injury Risks Muscles are crucial in maintaining mobility and reducing the risk of falls and fractures. Strong muscles support the bones and joints, helping stabilize the body during movement, increasing balance, and reducing the risk of injury. Also, muscles help maintain the coordination of the limbs, which is essential for preventing falls. When a person falls, strong muscles can help absorb the impact and reduce the damage, eventually lowering the risk of injuries.   Muscles Support Bone Health and Prevent Osteoporosis Muscles play an important role in supporting bone health and preventing osteoporosis. As muscles contract and relax during physical activity, they apply stress to the bones, which helps to stimulate bone growth and strengthen bone density. Strong muscles also help support the bones and prevent them from becoming weak and brittle. Osteoporosis is an age-related condition in which bones gradually become porous and fragile, making them more susceptible to fractures. By building and maintaining muscle mass, individuals can improve their bone health and reduce their risk of developing osteoporosis. Therefore, having healthy bones through healthy muscles is another way to achieve longevity, as bones are essential for maintaining mobility and preventing falls and fractures as we age.   Muscles Secrete Anti-inflammatory Cytokines Inflammation is a natural response to injury, infection, or stress. However, when inflammation becomes chronic, it can be the culprit for morbidities, including heart disease, diabetes, cancer, arthritis, bowel diseases, and even neurodegenerative diseases. Meanwhile, muscles can secrete anti-inflammatory cytokines, also known as myokines, that can reduce inflammation and prevent the development and progression of diseases. These cytokines work by suppressing the production of pro-inflammatory cytokines and activating immune cells that help to clear out inflammation and promote tissue repair.   Muscles Help Regulate Glucose and Insulin The myokines play a crucial role in maintaining glucose metabolism and insulin sensitivity. Myokines act as messengers between muscle cells and other organs, like the liver and pancreas, to help regulate glucose uptake, insulin secretion, and sensitivity. Myokines can also directly affect glucose metabolism by increasing insulin-stimulated glucose uptake and reducing inflammation, preventing insulin resistance. When muscles are active during physical activity, they require energy from glucose, which is taken up from the bloodstream. This process helps further reduce blood glucose levels and improve insulin sensitivity. Therefore, regular exercise that builds and maintains muscle mass can help increase myokine production, improve glucose metabolism, and reduce the risk of developing metabolic disorders such as diabetes.   Evidence for Muscle as a Predictor of Longevity To test the hypothesis that having more muscle in older adults will help achieve longevity, scientists from the David Geffen School of Medicine at UCLA Los Angeles, California, have designed one of the largest-scaled studies in this field. The study was published in the American Journal of Medicine and found that the risk of all-cause mortality was 19% lower in older

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Uncategorized

Benefits of High-intensity Interval Training May Include Improved COPD

Overview Lung diseases are a severe health concern affecting millions worldwide, causing significant morbidity and mortality. Patients, especially those over 40, are particularly vulnerable to respiratory problems, and the prevalence of lung diseases is increasing due to the aging population, pollution, and lifestyle factors. These conditions include chronic obstructive pulmonary disease (COPD). The detrimental impact of this disease is often devastating, limiting the patient’s ability to perform everyday tasks, reducing their quality of life, and leading to premature death. Fortunately, emerging exercise techniques, such as high-intensity interval training (HIIT), offer hope to those who suffer from lung diseases. Studies have shown that it can improve lung function, reduce inflammation, and improve overall fitness. This article reviews the research published in the Journal of Respiratory Medicine to explain how patients can overcome obstacles in exercising and improve their physicality, leading to a better quality of life by implementing HIIT.   High-intensity Interval Training Improves COPD Outcomes in Patients Aged 40 and Older What is High-intensity Interval Training (HIIT)? Definition High-intensity interval training (HIIT) is a form of exercise that has recently gained popularity as an alternative to traditional steady-state cardio. HIIT involves alternating periods of intense exercise with recovery periods of low-intensity activity or rest. The typical HIIT session lasts between 20 and 30 minutes. However, the exact time can vary depending on the individual’s fitness level and goals.   Mechanisms The primary mechanism of action behind HIIT is related to its metabolic and cardiovascular benefits. During intense exercise, the body is forced to work at a high intensity, which can increase the production of ATP, the body’s primary energy source. This phenomenon, in turn, can increase the body’s metabolic rate, which can help burn body fat and improve cardiovascular health. Also, HIIT can increase muscle mass and insulin sensitivity, reducing the risk of diabetes and other metabolic diseases. HIIT also increases excess post-exercise oxygen consumption (EPOC). EPOC is the oxygen debt the body must repay after exercise to return to its pre-exercise state. Therefore, the body keeps burning more calories even at rest for several hours.   Benefits Maximize workout efficiency Improve overall fitness levels Burn more calories after a workout Assist muscle growth and fat loss Improve strength, endurance, and agility Enhance cardiovascular and metabolic health Challenge the body to work at maximum capacity   What is Chronic Obstructive Pulmonary Disease (COPD)? Definition Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease that affects the airways, making breathing difficult. The condition is characterized by obstructed airflow, which causes shortness of breath, coughing, and wheezing. COPD is typically caused by smoking or exposure to other harmful pollutants over a prolonged period.   Symptoms Chronic cough Shortness of breath Fatigue and wheezing Chest tightness Frequent respiratory infections Unintended weight loss   Causes Cigarette smoking (the leading cause) Exposure to air pollution, chemical fumes, or dust Genetics (a rare condition called alpha-1 antitrypsin deficiency can cause COPD)   Treatment While there is no cure for COPD, several treatments are available to help manage the symptoms and slow down the progression of the disease. Medications (bronchodilators) can reduce inflammation and open up the airways Pulmonary rehabilitation programs can improve lung function and exercise tolerance Oxygen therapy can improve oxygen levels in the blood Surgery (lung volume reduction surgery or lung transplantation)   How Are HIIT and COPD Related? Increased Oxygen Uptake and Delivery The lungs are responsible for bringing oxygen into the body and removing carbon dioxide, making them an essential component of the respiratory system. During exercise, the body requires more oxygen to produce energy, so the lungs must work harder to supply this oxygen. Regular workout makes the lungs more efficient at delivering oxygen across the body, allowing for adaptation to a higher intensity when necessary. This phenomenon is particularly true for HIIT, a form of exercise alternating between short, intense bursts of activity and periods of rest or low-intensity exercise. Thus, HIIT increases lung capacity and function, making it an effective form of exercise for those with COPD.   Cardiovascular and Respiratory Health Also, HIIT can improve cardiovascular health, which can benefit those with COPD. This phenomenon is because the cardiovascular and respiratory systems are closely linked. For example, during a HIIT workout, the heart works harder and pumps more blood to the lungs, increasing lung capacity over time. As a result, the lungs can take in more oxygen and deliver it to the tissues, improving overall lung function.   Enhanced Angiogenesis in the Lungs HIIT can also increase the number of tiny blood vessels, or capillaries, in the lungs. These capillaries help exchange oxygen between the lungs and the bloodstream. By increasing the number of capillaries in the lungs, HIIT can improve the efficiency of this exchange process, leading to better oxygen uptake and delivery.   Benefits of HIIT for Individuals With COPD Improve the Pulmonary Function Pulmonary function refers to the ability of the lungs to take in oxygen and expire carbon dioxide. In individuals with COPD, this function is often impaired, leading to difficulty breathing, fatigue, and reduced quality of life. However, research has shown that HIIT can improve pulmonary function and mitigate the adverse effects of COPD. HIIT increases lung capacity, improves oxygen uptake, and reduces breathlessness. The short bursts of high-intensity exercise in HIIT allow the body to adapt to increased workloads, improving cardiovascular fitness. Also, HIIT strengthens the lung muscles, allowing individuals to breathe more efficiently and with less effort. By improving pulmonary function, HIIT helps individuals with COPD perform daily activities more efficiently and avoid exacerbations. Moreover, HIIT can be tailored to the individual’s fitness level and disease severity, making it a safe exercise technique for COPD.   Overcome Exercise Intolerance COPD patients often experience exercise intolerance. The inability to breathe efficiently leads to breathlessness, which can cause fatigue and discourage physical activity. Also, the energy required to breathe for individuals with COPD is more than for healthy individuals, leading to reduced exercise capacity. This intolerance is a significant concern and

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