The journey is unlimited. Learning should be too.

Peak Human is unfettered innovation. That value is based on our lifelong belief in continuous learning. Dr. Sanjeev Goel has spent decades acquiring knowledge from the front edge of medical innovation and now shares his insights with you.

Welcome to the Learning Center.

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Quercetin: The Health Benefits Unravelled

Quercetin is the most abundant dietary flavonoid. Quercetin is present in many grains, fruits, and vegetables. It is also linked to an array of health benefits while displaying minimal side effects. Let’s unravel what quercetin is, benefits, side effects, and lastly, how to make the most of quercetin with Peak Human. RELATED: Strategies to Enhance Your Immunity During COVID-19   What Is Quercetin? Quercetin is a natural pigment. More specifically, it is a flavonoid that is derived from plants. It’s in foods such as berries, broccoli, cherries, citrus fruits, grapes, and others. It’s also in drinks such as green tea and red wine. Plus, Quercetin can be consumed safely as a dietary supplement.   Quercetin Benefits Quercetin benefits can vary. Since quercetin is also a potent antioxidant, it’s linked to many potential health benefits.   Reduces Inflammation Persistent inflammation causes an abundance of health problems. One reason our bodies experience persistent inflammation is due to high levels of free radicals. An excess of free radicals will alter cellular functions leading to chronic, sometimes even degenerative diseases. Studies show quercetin may be able to help here by reducing inflammation.   Reduces Blood Pressure Hypertension occurs when blood pressure is abnormally high. It is measured by two numbers: systolic and diastolic. Systolic represents the pressure in blood vessels when the heart beats. Diastolic represents the pressure in blood vessels between heartbeats. Studies show that quercetin helps reduce blood pressure in people with hypertension. In another study, people consumed 500 mg of quercetin per day over five weeks. As a result, the individual’s systolic and diastolic numbers were both reduced.   Other Potential Quercetin Benefits In addition, there are other potential quercetin benefits. This includes enhanced exercise performance, blood sugar control, anticancer effects, protection against dementia, and reduced markers of aging. But, compared to the other quercetin benefits, most of this research has been on animals. More research on humans is required.   Quercetin Side Effects Quercetin is relatively safe to consume either through natural sources or via a supplement. Yet, with anything, there are potential side effects. In some cases, consuming more than 1,000 mg of quercetin in a day may lead to mild discomforts such as headaches or stomach aches. Beyond that, quercetin is found in many foods and is safe to consume. RELATED: Peak Human Labs Podcast – Why I’m A Fan of Freak Fitness Online    Make The Most Of Quercetin with Peak Human As mentioned earlier, quercetin is a common flavonoid. It is present in many healthy dietary choices, such as berries, broccoli, green tea, and red wine. But, most people will get between 5 and 40 mg a day from such sources. To avoid mild side effects that come with consuming more than 1000 mg, Peak Human has developed a supplement called Senolytic Complex with the optimal amount of quercetin.   If you have questions about quercetin benefits, connect with us and learn more. At Peak Human, our team of healthcare professionals is dedicated to helping you reach your ‘peak’ health with a custom whole-person approach. Using the most cutting-edge, science-backed biohacking and aesthetic tools, technologies, and treatments available today, we help you achieve the highest physical/cognitive performance state, leading to an improved overall quality of life. For questions or to book an appointment, don’t hesitate to contact us. Get personalized support and insight from expert physicians. Up Next: Senolytic Therapies As A Way To Improving Lifespan Mushrooms With Yarrow Willard – Peak Human Labs Podcast The Science Behind PRP

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middle aged couple looking at their computer | How to Measure Your Immunological Age and Prevent Disease
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How to Measure Your Immunological Age and Prevent Disease

As we age, our immune system becomes less functional. This is called immunosenescence. It starts to affect people later in life. A dysfunctional immune system leads to an increased risk of health issues. Although immunosenescence is linked to chronological age, there has been ongoing research that shows each individual also has an immunological age. If you can get an accurate measure of your immunological age and make necessary changes, it may help prevent different diseases. RELATED: Peak Human Labs Podcast – Why I’m a Fan of Freak Fitness Online   How To Understand Immunological Age To understand your immunological age, we must first understand immunosenescence. Immunosenescence occurs with people mainly over the age of 60. Why? You become at a higher risk for infections, autoimmune diseases, and malignant tumors as you get older. This dysfunction is associated with a remodeling of lymphoid organs. Lymphoid organs, which include bone marrow and the thymus, create lymphocytes that filter out and trap pathogens from harming your body. Yet, immunologists now understand that your immune system doesn’t always correlate directly with your age. As immunologist Shai Shen-Orr says, “Some 60-year-olds have the immune system of a 40-year-old, some are more like an 80-year-old.” Thus, age really is just a number.   How To Measure Yours Our immune system is as complex as the brain. It has both innate and adaptive systems. Our innate immune system is the first layer of defense. It consists of neutrophils and macrophages. They attack general pathogens. Our adaptive immune system is the second layer of defense. It consists of antibodies, B-Cells, and T-Cells. They attack specific pathogens. Our adaptive system is what helps us not get certain diseases twice. We measure our immunological age, like our biological age, using chemical tags. Immunologists will progressively add tags to genes to measure how cells within our immune system will react. This determines the trajectory of how the immune system is aging. For example, look at neutrophils, the most common type of white blood cell. As mentioned earlier, these are cells that are part of our innate immune system. As we age, they start misbehaving and become less efficient. This increases inflammation and makes us more susceptible to harmful bacteria. Another example is T-Cells. They originate in the thymus. They are part of the adaptive immune system. Without them, you are limited in your ability to defend yourself against novel pathogens. Immunologists will study this behavior of cells to measure immunological age.   Benefits of Measuring Your Immunological Age By measuring your immunological age, you are better able to get an accurate picture of how healthy your immune system is. Suppose you have a clearer understanding of your actual immunological age. In that case, you can see how likely you are to get ill. At that point, you can take the necessary steps to improve your immune system and lower the risk of getting sick. As a result, you have the potential to turn back your immunological clock. Great places to start are to stop smoking, start exercising and take vitamins such as Vitamin E, Vitamin D, and Zinc. There even seems to be benefits for the immune system by practicing caloric restriction or fasting. RELATED: Strategies to Enhance your Immunity during COVID-19   Discover Your Immunological Age With GlyCan Age Discovering your immunological age is the first step to preventing infectious diseases. Despite immunological age measurement being still relatively new, Glycan Age and its team of qualified specialists are here to help you succeed. It starts with a quick and easy finger prick. Next, Glycan Age will run different tests on your sample. This ensures an accurate measure of your actual immunological age. You will be able to view your results on a personal dashboard and add profile details to help. From there, you will receive complimentary guidance from a Care Team Specialist. By working together, you can discover ways to help improve your health. Start your wellness journey today with Glycan Age.   If you have questions about measuring your immunological age and preventing disease, connect with us and learn more. At Peak Human, our team of healthcare professionals is dedicated to helping you reach your ‘peak’ health with a custom whole-person approach. Using the most cutting-edge, science-backed biohacking and aesthetic tools, technologies, and treatments available today, we help you achieve the highest physical/cognitive performance state, leading to an improved overall quality of life. For questions or to book an appointment, don’t hesitate to contact us. Get personalized support and insight from expert physicians. Up Next: Senolytic Therapies As A Way To Improving Lifespan What Foods Are Best For Your Health “Fasting While Eating” – The Fasting Mimicking Diet (FMD)

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The Use of ‘Cold’ Tech to Improve Your Deep Sleep

We have all heard the phrase “quality over quantity.” In terms of sleep, this adage rings true. Quality sleep, or deep sleep, is more important than how much sleep you get. Learn how Chilisleep and its innovative ‘Cold’ Tech has the potential to improve your deep sleep. RELATED: What Foods Are Best For Your Health?   What Is Deep Sleep? Deep sleep is what we need to feel refreshed in the morning. If our deep sleep is disrupted, we feel groggy in the morning. When we sleep, we go through 90-minute cycles alternating between REM and non-REM sleep. Deep sleep comes in the last non-REM cycle. Here is a breakdown of the stages. Stage 1: The first stage of Non-REM sleep lasts several minutes as we begin to fall asleep. Our body functions slow down and brain waves slow, and our muscles start to relax. Stage 2: The second stage of Non-REM sleep makes up about half of our total sleep cycle. Your body and brain continue to relax, your core temperature starts to drop, and your eye moments now stop. Stage 3 & 4: The third and fourth stage is when we experience deep sleep. Our heartbeat, breathing, and brain waves will be at their slowest rate. In this stage, it is difficult to wake up even if there are loud noises. The third stage lasts between 45-90 minutes. As the night goes on, deep sleep stages become shorter. Stage 5: In the fifth stage, after roughly 90 minutes of Non-REM sleep, we experience our first REM sleep stage. During this stage, a couple of things happen. Our eyes move rapidly. Our heart rate increases, and we breathe faster. Our limbs may become paralyzed. Also, since our brain activity increases, we experience dreams.   What Are The Benefits? Increased glucose metabolism, which supports short term and long term memory and learning Increased hormone secretion Cell and Energy restoration Increased blood supply for muscles Enhanced growth and repair of muscle tissues and bones Strengthened immune system   How Do You Know If You’re Getting Enough Of It? An obvious sign that you are not getting enough is that you wake up feeling exhausted. If that’s the case, you have two options to track your sleep. One, a wearable device like a smartwatch, although this may not be reliable. Two, get work with a sleep center to get a polysomnography (PSG) test which measures body movements, brain waves, breathing rate, heart rate, and oxygen levels.   What Happens To Your Body When You Don’t Get Enough Deep Sleep? If you choose to ignore the fact you don’t get enough deep sleep, there are many negative consequences. Alzheimer’s diseases, diabetes, heart disease, and stroke are linked to a lack of quality sleep. Add study   Tips On How To Increase Deep Sleep There is plenty of general advice out there to get more deep sleep. Tips include: Following a routine schedule. Getting plenty of exercise during the day. Avoiding caffeine before bed. Making your room as dark as possible.   The most overlooked but most important factor that leads to deep sleep is temperature. Deep sleep requires a cooler body temperature. Chilisleep uses precise science to help both hot and cold sleepers receive deep, restorative sleep every night. Here are three products that can help.   chiliBLANKET Experience this unique 15lb, hydro-capable cooling weighted blanket designed to deliver restorative, deep sleep. Use the code PEAKHUMAN10 for 10% off chiliBLANKET.   Cube Sleep System This pioneering system can do it all. It includes a reversible hydro-powered mattress pad, thermal regulating control units, and a remote! Use the code PEAKHUMAN20 for 20% off chiliPAD.   OOLER It’s time to take your deep sleep to the next level. This advanced system is equipped with a hydro-powered thermal range of 55-115°F (13-46°C). Plus, it has a reversible hydronic pad and control unit(s). You can connect it to the OOLER app to optimize sleep schedules. Use the code PEAKHUMAN20 for 15% off OOLER. RELATED: The Scoop On Improving Brain Performance With Binaural Beats   Remember, the quality of sleep trumps the number of sleep hours. It is crucial that the body experiences consistent deep sleep. That way, you can wake up feeling refreshed and ready to take on the day. ‘Cold’ Tech like Chilisleep is your opportunity to improve your deep sleep and make the most of each day.   If you have questions about how the use of ‘Cold’ Tech can improve deep sleep, connect with us and learn more. At Peak Human, our team of healthcare professionals is dedicated to helping you reach your ‘peak’ health with a custom whole-person approach. Using the most cutting-edge, science-backed biohacking and aesthetic tools, technologies, and treatments available today, we help you achieve the highest physical/cognitive performance state, leading to an improved overall quality of life. For questions or to book an appointment, don’t hesitate to contact us. Get personalized support and insight from expert physicians. Up Next: Peak Human Labs Podcast – Why I’m a Fan of Freak Fitness Online DNA Genetic Testing – Worth it? Senolytic Therapies As A Way To Improve Lifespan

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blue background with bubble splash | The Evidence Behind the Use of Hydrogen Water to Improve Your Health
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The Evidence Behind the Use of Hydrogen Water to Improve Your Health

Hundreds of scientific studies have shown that hydrogen water helps your body heal faster, gives you more energy, speeds your recovery, and helps your body fight off many different diseases and ailments. RELATED: Quercetin: The Health Benefits Unravelled   Hydrogen Water — Harness the Healing Power of Nature’s Most Powerful Antioxidant Search “hydrogen water scientific studies,” and you’ll find an abundance of science-backed research highlighting the effects and benefits of consuming this simple but effective “miracle drink.” Hydrogen water has been praised for its power to slow down the aging process, increase energy, and improve muscle recovery after a workout, and so much more. So, what are the health experts talking about, and is hydrogen water worth trying?   What Exactly is Hydrogen Infused Water? Hydrogen water is simply – regular water with dissolved molecular hydrogen gas (H2). Hydrogen gas is separated from a stream of water during electrolysis. Then, it’s dissolved into a second stream of water. There is no difference in nutritional value compared with regular water. It contains zero calories, carbs, fat, and protein. But the difference in benefits of hydrogen-infused water lies in its increase of anti-inflammatory, antioxidant, and other health properties.   Hydrogen Water Benefits Staying hydrated generally is a great way to stay healthy. Adding hydrogen to the mix increases those benefits. Hydrogen’s therapeutic benefits are displayed in nearly 1,000 scientific studies and articles, spanning over 12 years. Based on preliminary studies, the following are potential health benefits:   Disease Prevention Hydrogen has been shown to reduce oxidative stress and inflammation, which is a leading cause of disease. Antioxidants impact our bodies via external sources, for example, industrial chemicals or the sun. The surplus of free radicals causes oxidative damage to biomolecules (DNA, proteins, lipids). In time this can lead to many chronic diseases such as: Atherosclerosis Cancer Cardiovascular diseases Chronic inflammation Diabetics Myocardial infarction Post-ischemic perfusion injury Rheumatoid arthritis Septic shock Stroke Aging and other degenerative diseases in humans   Enhance Athletic Performance Hydrogen water can improve exercise-induced decline of muscle function. Researchers studied the effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in soccer players. The results showed that consumption of hydrogen water reduced blood lactate levels, increased muscle energy, and, therefore, improved recovery times.   What’s the Most Affordable and Effective Way to get Hydrogen Water in Your Home? Some suppliers bottles of hydrogen water with the gas already added to it. You can also buy hydrogen water tablets which you drop into a glass of water to add the gas. But, these options are not particularly efficient or practical, especially if you intend to drink all your water hydrogenated. Hydrogen water machines like Echo Systems are water machines that fit over or under your countertop and connect to your water supply. As you draw the water from the designated tap, regular tap water is converted at a rate of around one liter per minute. Some also connect to your fridge. The best models will come with built-in water filtration systems, which is crucial to remove all the toxic substances commonly found in tap water.   Takeaways Hydrogen water is regular water with dissolved molecular hydrogen gas (H2). Hydrogen has been shown to reduce oxidative stress and inflammation, which is a leading cause of disease. Drinking hydrogen water would be an effective fluid hydration strategy for athletes. The most affordable and effective way to get hydrogen water is via a hydrogen machine like the Echo Systems   If you have questions about hydrogen water or any of the conditions discussed here, connect with us and learn more. At Peak Human, we use an Echo Systems unit for Hydrogen water but do not receive any commission or financial benefit from you choosing them. We have fully passed on the discount we received from them to you. At Peak Human, our team of healthcare professionals is dedicated to helping you reach your ‘peak’ health with a custom whole-person approach. Using the most cutting-edge, science-backed biohacking and aesthetic tools, technologies, and treatments available today, we help you achieve the highest physical/cognitive performance state, leading to an improved overall quality of life. For questions or to book an appointment, don’t hesitate to contact us. Get personalized support and insight from expert physicians. Up Next: Plasma Exchange: A revolutionary New Way to Reverse Aging New Approach To Eliminating Senescent Cells The Relationship Of Telomeres To Biological Aging Explained

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woman holding her head | EMF Radiation: Is It Harmful and How to Protect Yourself
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EMF Radiation: Is It Harmful and How to Protect Yourself

Today, electronic devices such as smartphones, tablets, etc. are everywhere, and they all produce EMF radiation. Concerns are well documented in the media, but should you be worried? RELATED: The Relationship Of Telomeres To Biological Aging Explained   What is EMF Radiation? EMF radiation is short for electric and magnetic field radiation. The sun, since its creation, has been sending out waves that create EMF radiation. The visible light we can see from the sun is actually the EMF energy radiating out. When indoor lighting and power lines spread across the world at the turn of the 20th century, scientists discovered they were sending off EMFs just as the sun does. More recently, and with advancements in technology, medical equipment like CT scans and X-rays have also been found to emit EMFs. With over 90 percent of the world having access to electricity, and so many electronic devices and appliances around us, there is a lot of EMF radiation exposure. There are also  two different types that you might be exposed to: High-frequency EMF radiation: this type has an ionizing effect and can damage DNA or cells directly. They are typically found in medical devices such as X-ray machines and CT scanners, albeit only in small amounts. Other sources include radioactive elements and UV radiation from the sun or tanning beds. Low- and mid-frequency EMF radiation: contrary to the high-frequency type, this one is non-ionizing. Non-ionizing EMF radiation comes from both human-made and natural sources. One example of the latter is the earth’s magnetic field. For human-made EMF, there are two further types: Extremely low-frequency EMF (ELF-EMF): this can come from a variety of sources, such as power lines and some personal appliances such as electric shavers, hairdryers, etc. Radiofrequency radiation: this radiation is emitted from wireless devices, like your smartphones, tablets, and laptops. It can also come from radio and TV signals, satellite stations, and MRI machines.   What Can EMF Radiation Do to You? Although EMF radiation is almost everywhere around us, scientists generally agree that EMF is rarely fatal. However, health implications that warrant attention have been observed. High-frequency EMF radiation can damage our DNA and cells, especially from long exposure. Low and mid-frequency EMF radiation have also been measured in tests in which some symptoms have been found. They include: Headache Dizziness Memory loss Loss of concentration Sleep disturbance Anxiety Depression Nausea Skin burning and tingling   In even more severe cases, glioma, a type of brain cancer and a specific type of leukemia have been observed. The consensus is that there needs to be more monitoring to confirm that these severe cases are the direct result of EMF radiation.   EMF Radiation Protection? Generally, EMF radiation risks are low for more lifestyles. But, some EMF radiation protection measures may help those concerned about their exposure levels. Here are some approaches you could take: For low- and mid-frequency EMF radiation, reduce use of electronic devices. For high-frequency EMF radiation, limit exposure to X-rays and other medical equipment as well as to direct sunlight.   If you have questions about EMF radiation or any of the conditions discussed here, connect with us and learn more. At Peak Human, our team of healthcare professionals is dedicated to helping you reach your ‘peak’ health with a custom whole-person approach. Using the most cutting-edge, science-backed biohacking and aesthetic tools, technologies, and treatments available today, we help you achieve the highest physical/cognitive performance state, leading to an improved overall quality of life. For questions or to book an appointment, don’t hesitate to contact us. Get personalized support and insight from expert physicians. Up Next: The Evidence Behind the Use of Hydrogen Water to Improve Your Health The Use of ‘Cold’ Tech to Improve Your Deep Sleep Quercetin: The Health Benefits Unravelled

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The Science Behind The Use of GHRP and GHRH Peptides

Despite our body’s natural response to disease and damage, what if we could harness that power and accelerate it through various methods? It sounds like science fiction, but GHRP and GHRH peptides can do precisely that. We are one step closer to speeding up the treatment for injuries and diseases. RELATED: The Science Behind PRP   How GHRP and GHRH Peptides Work What Is Growth Hormone (GH)? Growth hormone (GH) is produced and released by anterior pituitary cells called somatotrophs. It promotes the development of almost all bodily tissues, including bone. GH is crucial for children’s normal physical growth. GH levels rise gradually throughout infancy and peak during puberty. GH secretion rises in reaction to reduced food consumption and physiological stress but falls in response to food intake. However, some people are affected by GH secretion disorders, resulting in a deficiency or excess of GH. People with growth hormone deficiency can have: Short stature and dwarfism Reduced muscle strength and mass Thin and dry skin Poor bone density (leading to osteoporosis) Fatigue Poor memory Depression Increased body fat around the waist   People with growth hormone excess can have: Extreme height Features of acromegaly such as a prominent jaw, a large nose, and large hands and feet, as well as enlargement of most other tissues, including the tongue, heart, liver, and kidneys Severe headaches Visual deficit High blood pressure (hypertension) Cardiovascular disease Arthritis Higher risk of malignant tumors of the large intestine   People who have a growth hormone deficiency as a disorder might have injections of GH. GH injections can: Increase exercise capacity Increase bone density Grow muscle mass Reduce body fat   The Role of Growth Hormone-Releasing Hormone (GHRH) The neuropeptide, growth hormone-releasing hormone (GHRH), is produced in the hypothalamus to stimulate GH release in the pituitary gland. GHRH is a key regulator of cellular functions in many cells and organs. The human body produces GHRH pulses throughout the day, with a large amount released as we start to sleep. Exercise, food, and stress can all affect this secretion pattern. Studies have shown that GHRH might play a role in: Wound healing Cardiac repair Regeneration and repair of tissue Regulation of cellular and tissue aging Promotion of follicular maturation Regulation of spermatogenesis in Leydig cells   However, the exact physiologic and biochemical processes by which GHRH usage accelerates wound healing are unknown. Although it provides a therapeutic intervention in pathophysiologic situations, further research is necessary to determine whether this mechanism is active during routine wound healing.   The Role of Growth Hormone-Releasing Peptides (GHRPs) Growth hormone-releasing peptides (GHRPs) are synthetic, non-natural peptides that act as stimulants for the natural release of growth hormones. One of the first studies in 1984 identified the peptide. Since then, studies have documented its ability as a potent ghrelin receptor booster. The peptide ghrelin is produced from the gastrointestinal tract, particularly the stomach, and later harmonizes with GHRH to stimulate GH secretion. Ghrelin has a multifaceted role and, amongst other things, stimulates food intake, regulates weight, increases body mass, regulates metabolism, is involved in cancer development, and supports bone formation. RELATED: How Your Immune System Can Benefit From Peptide Therapy   Ipamorelin Is a GHRP That Ensures the Benefits Without Negative Side Effect One of the most interesting GHRPs is Ipamorelin. It is a pentapeptide hormone which is a growth hormone secretagogue combined with a small molecule ghrelin mimetic that helps promote the significant release of growth hormone. So, how does Ipamorelin work? When given during a GHRH pulse or in combination with GHRH, Ipamorelin has a synergistic effect. The synergy is due to somatostatin suppression, and since Ipamorelin increases GH release per-somatotrope. In contrast, GHRH increases the number of somatotropes that produce GH. Ipamorelin, while being a stable substance, stimulates the production of GH without adverse side effects. The benefits of Ipamorelin include: Increased muscle mass Increased bone density, thereby preventing fractures Better capacity for exercise Boosted energy levels Decrease body fat Reduced risk of heart disease.   In vivo and in vitro studies, Ipamorelin has proven to be very powerful and selective. It has also demonstrated high degrees of safety and tolerability in different human clinical trials. Ipamorelin does not affect pituitary hormones like cortisol and does not cause hunger. The emergence of GHRP and GHRH peptides has opened the door to treating injuries and diseases more effectively. As a promising GHRP, Ipamorelin can offer a solution to many health problems without the need to cope with any potential unwanted side effects. For a 10% discount on all peptides visit canlabs.net and use code goel10.   If you have questions about GHRP and GHRH peptides or any health problems discussed here, connect with us and learn more. At Peak Human, our team of healthcare professionals is dedicated to helping you reach your ‘peak’ health with a custom whole-person approach. Using the most cutting-edge, science-backed biohacking and aesthetic tools, technologies, and treatments available today, we help you achieve the highest physical/cognitive performance state, leading to an improved overall quality of life. For questions or to book an appointment, don’t hesitate to contact us. Get personalized support and insight from expert physicians. Up Next: How to Measure Your Immunological Age and Prevent Disease The Science Behind the Use of Curcumin for Healthy Aging Plasma Exchange: A revolutionary New Way to Reverse Aging

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couple doing yoga outdoor | Immunosenescence: The Connection Between Metabolism, Immune System, and Aging
Aging

Immunosenescence: The Connection Between Metabolism, Immune System, and Aging

Most people know that as we age, our metabolism slows, and our immune systems decline (immunosenescence), causing unwanted side effects and putting us at risk of disease. Not only are these two biological functions closely linked, but we can also actually fight the effects of aging on metabolism and reduce our immune age. RELATED: DNA Genetic Testing – Worth it?   At 50, some people have the immune system of a 30-year-old, others a 70-year-old! What is Immunosenescence? The gradual natural deterioration of our immune systems as we age, called immunosenescence, starts surprisingly early in life, during puberty. However, it’s not until around 60 years old that it starts to impact health when we are more likely to get seriously ill or die as a result. Different lifestyle factors can accelerate immunosenescence – people who smoke, who are overweight, or are sedentary are likely to have an immune system that is older than their chronological years.   What is Metabolism? Our metabolism represents all the chemical processes that occur in the body; they are the functions that keep us alive and our organs working normally, such as breathing, digestion, and cellular repair. To do this, energy is required, and the minimum amount needed to carry out all the chemical processes is called the basal metabolic rate (BMR). Four factors influence your metabolism: Resting metabolic rate (RMR) – how many calories you burn to function while sleeping. Non-exercise activity thermogenesis (NEAT) – how many calories you burn from regular activities (standing, fidgeting). Thermic effect of food (TEF) – how many calories you burn from eating and digesting food. Exercise – how many calories you burn through exercise.   Your height, muscle mass, hormones, and age also affect the speed of your metabolism.   Metabolism and Aging Research tells us that our metabolism slows as we get older. Reasons for this include:   Less activity. Older people are typically less active.   Sarcopenia (natural loss of muscle mass as we age). Increased muscle mass means a higher RMR because muscle cells are more active than fat cells. So, as we age and naturally lose our muscle mass, our RMR reflects this.   The metabolic process slows naturally. Our RMR slows naturally because the main functions that control this become less efficient as we age. One study between older and younger adults recorded an 18% difference meaning the older adults were burning 101 fewer calories per day.   The Immunosenescence Link to Metabolism The reason why our metabolism and our immune system are closely linked is that our body’s ability to defend itself against pathogens depends on energy. Interestingly, immune cells can reuse “waste” products from metabolization to be more efficient. For example, neutrophils (a type of white blood cell) produce hydrogen peroxide, which the immune system uses to kill pathogens. The intricate link is far more detailed, but this area of immunometabolism is fast becoming a popular study subject in the search for causes of disease and better medicines. Recent research on manipulating the metabolic pathways of T-cells, cancer cells, or immune suppressor cells can suppress tumor growth and increase anti-cancer immunity. The delicate balance has an effect on our risk of diseases, including non-communicable diseases such as diabetes, obesity, and cardiovascular disease. So, by understanding our immunometabolism more, we can combat those diseases.   How to Increase Metabolism – 6 Easy Ways You can do many things to help boost your metabolism and combat the effects of aging on your metabolism and your immunosenescence. Here’s how to boost metabolism:   1. Do High-Intensity Interval Training (HIIT) This training technique is all about extreme anaerobic exercise with brief rest periods in between. As well as burning energy while you exercise, HIIT induces your body to burn kilojoules after exercise, known as the “afterburn effect,” as your muscles use energy to recover. In fact, 45-minutes of vigorous exercise can increase metabolic rate for 14 hours after exercising.   2. Get Enough Sleep Does your metabolism slow down when you sleep? Lack of sleep can slow your metabolism but luckily, catching up on sleep can reverse this effect. A study on resting metabolic rate (RMR) showed it was significantly reduced after sleep restriction and rebounded to normal levels after one night of 12-hour recovery sleep. With just 4 hours of sleep per night, metabolism dropped 2.6% compared to people who got 10 hours per night.   3. Try Weight Lifting By exercising and building muscle mass, you can speed up your metabolism. The harder your muscles work, the more energy they burn, and regular exercise teach your body to burn kilojoules at a faster rate, even when at rest. In a study of older adults whose metabolism was tested before and after 26 weeks of resistance training, their resting energy expenditure increased by 6.8%.   4. Drink Green Tea Drinking green tea can increase metabolism by around 4-5%, as different studies report. Just three cups per day can increase metabolism by 4% over 24 hours.   5. Take Supplements Dietary supplements and their effect on metabolism and weight loss have been the basis of studies for some time. It is generally known that supplements with a combination of thermogenic ingredients can increase RMR, but that depends on the active ingredients and the combination.   6. Eat Protein-Rich Foods Your body burns more calories when it digests and absorbs protein into the body. Known as the thermic effect of food (TEF), protein has a higher TEF than foods high in fat and carbohydrates. Also, because protein is essential for muscle health, especially in older adults, it helps combat an aging metabolism by protecting muscle mass and fighting sarcopenia. Despite our metabolism slowing down as we age and affecting our immune system, there are ways we can combat this and reduce our immune age.   If you have questions about immunosenescence or any conditions discussed here, connect with us and learn more. At Peak Human, our team of healthcare professionals is dedicated to helping you

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The Science Behind DHH-B | A Natural Supplement For Your Mood

In today’s high-paced world of economic uncertainty where careers and fortunes can come and go in the time it takes to download an app to a smartphone, more young people are experiencing negative physical effects from anxiety disorders usually associated with people their parent’s age. While technology certainly can provide answers, often the best solutions are derived from nature. A new take on an old remedy, DHH-B, the main ingredient in an herbal / plant-based solution, has been found to prove effective yet safer than more commonly used chemical treatments. RELATED: 5 Proven Health Benefits Of Liquid Chlorophyll   An Alternative Natural Remedy for Anxiety Relief Throughout the second half of the 20th century, it became quite common for doctors to prescribe Valium, a medication of the Benzodiazepine group as an anxiolytic in order to treat conditions such as anxiety, insomnia and even alcohol withdrawal.  Unfortunately these drugs lower brain activity and with repeated use often carry a host of negative side effects including but not limited to decreased motor function, difficulty with respiration, continued feelings of disorientation and even drug withdrawal symptoms. Fortunately an ancient remedy, often unknown even to those well versed in alternative medicine can be substituted for harsh and even dangerous prescription depressants. Magnolia Bark, or more specifically DHH-B extracted from it, can be used as a safer and non-addictive treatment for anxiety disorders. DHH-B or dihydrohonokiol-b is an organic compound that is derived from a magnolia bark extract called honokiol.   Benefits of DHH-b Honokiol has been medically proven to be anti-inflammatory, anti-bacterial, and anti-allergic. It can be used to alleviate pain, heal cerebrovascular injuries, treat epilepsy, and even lessen the symptoms of cognitive disorders including Alzheimer’s disease. DHH-B contains a significantly larger amount of honokiol proven to have an anti-anxiety effect similar to more common prescription drugs but minus the negative side effects long-term users often experience from depressants. Unlike conventional depressants, it can be used during the daytime in a work environment to effectively ease anxiety attacks as well as helping to fall asleep at night. Oddly enough, even in a market saturated with natural supplements for anxiety, Magnolia Bark and its positive effects are not as well known as other more popular remedies like St John’s Wort, though it has been proven to be at least as effective. It works by boosting an important neurotransmitter called “GABA” that has a calming effect on the human nervous system. Since increased levels of GABA counteract the effects of general anxiety, it can aid with regulating health sleep cycles. Magnolia Bark’s main derivatives, honokiol and magnolol, help activate the endocannabinoid system located throughout the body, and can help to elevate moods, reduce inflammation and even relieve pain. Since it is an adrenaline inhibitor and suppresses cortisol – hormones associated with stress – magnolia bark can stimulate alertness and mental vigilance. DHH-b is now available as an anti-anxiety supplement, or anxiolytic and can be used as a natural alternative to Valium and other Benzodiazepines. *If you have been prescribed antidepressant medication recently then please consult with your doctor or other medical professionals before trying DHH-B.   Order DHH-B here. If you have questions about DHH-B or any of the conditions discussed here, connect with us and learn more. At Peak Human, our team of healthcare professionals is dedicated to helping you reach your ‘peak’ health with a custom whole-person approach. Using the most cutting-edge, science-backed biohacking and aesthetic tools, technologies, and treatments available today, we help you achieve the highest physical/cognitive performance state, leading to an improved overall quality of life. For questions or to book an appointment, don’t hesitate to contact us. Get personalized support and insight from expert physicians. Up Next: The Science Behind The Use of GHRP and GHRH Peptides In Regenerative Medicine Immunosenescence: The Connection Between Metabolism, Immune System, and Aging The Evidence Behind the Use of Hydrogen Water to Improve Your Health

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Senolytic Therapies as a Way to Improving Lifespan

Some scientists say we are just a few years away from creating drugs that delay or even prevent aging altogether. Still, the life-extension community has been excited about senolytic therapies for many years. More recently, scientific studies and early human trials reveal a growing number of compounds proven to increase healthspan. RELATED: How to Measure Your Immunological Age and Prevent Disease   Natural Senolytic Therapies You Can Take for Anti-aging A Background to Senolytic Therapies for Longevity Extending the human lifespan has a long tradition in many cultures. It has been the focus of the medical community, which continues to explore potential avenues in longevity. Senolytics, a medicine that selectively kills senescent cells (aging cells), is one such practice. Senescent cells are aged and malfunctioning cells that also affect normal cells and cause the body to become less capable of tissue repair. Inflammation control and protection against age-related diseases, cancer, or injury reduces, and the body becomes compromised. Individuals who amass more senescent cells seem to age quicker, and their biological clock ticks faster. Studies in mice found that by removing senescent cells, insulin resistance was alleviated, and cell dysfunction was improved. Many other animal studies have also recorded successful senolytic therapies.   Research There is now early evidence from human trials that confirm what the animal-based studies found about senolytic therapies as a way to improve life span. A 2019 report on how senolytics decrease senescent cells in humans used a combination of the senolytic leukemia drug dasatinib and the dietary supplement quercetin, previously shown to improve physical function in patients with idiopathic pulmonary fibrosis. In the new phase 1 trial, nine patients with diabetes-related chronic kidney disease were given the combination drugs for three days. Eleven days after the treatment had stopped, despite being completely eliminated from the system, the effects of the medicine appeared to last, and there was a significant reduction in the number of senescent cells. In another study, preclinical tests on the small molecule inhibitor UBX1325 showed it to eliminate senescent cells for patients with diabetic macular edema. This resulted in a positive impact on inflammation, reduction in vascular leakage, and improvement in retinal and visual function. The first phase of clinical trials is due to complete by October 2021.   Natural Senolytics A diverse variety of compounds, ranging from chemotherapy drugs to common dietary supplements, have been shown to have senolytic effects. You may have heard of the natural compounds ashwagandha, spirulina, and garlic extract, which are not strictly senolytics but can naturally increase killer cell activity and indirectly kill senescent cells. Some of the most powerful natural senolytics currently being studied and trialed include:   Fisetin Fisetin is one of the most potent senolytics. This flavenoid and natural yellow coloring agent is found in fruits and vegetables like apple, cucumber, persimmon, onion, and strawberry. The study of senolytic therapies on mice has been successful, demonstrating fisetin to have neurotrophic, anticarcinogenic, anti-inflammatory benefits, reduce senescent markers in tissues, reduce the risk of age-related diseases, and increase the risk of age-related diseases lifespan.   Quercetin Studies have shown this polyphenol to have a wide range of biological actions, including anti-inflammatory, anticarcinogenic, and antiviral activities and improving cardiovascular health. Due to recent studies, it is currently the most validated natural senolytics supplement.   Trans-Resveratrol This naturally occurring polyphenol is found in over 70 plant species and various human foods, notable grape skins. Evidence from animal and human studies reveals that the anti-inflammatory and antioxidant effects may prevent or act as a treatment against many non-communicable diseases such as neurodegenerative diseases, obesity, diabetes, cardiovascular diseases, and certain cancers.   Pterostilbene This natural dietary compound, the primary antioxidant component of blueberries, has increased bioavailability and demonstrated in multiple studies to have antioxidant effects. The preventative and therapeutic effects of pterostilbene have been connected to anti carcinogenesis, moderation of neurological disease, and improvement of diabetes, to name a few.   Curcumin Turmeric’s medicinal properties and the source of curcumin have been known for thousands of years. Anti-aging studies reveal that it aids in the management of inflammatory and oxidative conditions, as well as arthritis, anxiety, and high cholesterol. It has also been shown to help manage muscle soreness induced by exercise, therefore aids in the recovery and performance of athletes and active people.   Senolytic Complex for Longer Life The Senolytic Complex from Peak Human is a healthy aging support supplement that optimizes body function, protects from cell damage, and optimizes brain function. It contains all five of the above ingredients giving you the power to enhance your health. Senolytic therapies may provide an adequate treatment scope for a range of age-related diseases such as cancer, chronic kidney disease, and neurodegenerative disorders, which place a marked burden on healthcare systems worldwide. This field is still new, but early clinical trials are promising.   If you have questions about senolytic therapies or any of the conditions discussed here, connect with us and learn more. At Peak Human, our team of healthcare professionals is dedicated to helping you reach your ‘peak’ health with a custom whole-person approach. Using the most cutting-edge, science-backed biohacking and aesthetic tools, technologies, and treatments available today, we help you achieve the highest physical/cognitive performance state, leading to an improved overall quality of life. For questions or to book an appointment, don’t hesitate to contact us. Get personalized support and insight from expert physicians. Up Next: What Foods are Best for Your Health? A Treatment to Enhance Your Pelvic/Sexual Health DNA Genetic Testing – Worth it?

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Blog

Senolytic Therapies As A Way to Improving Life Span

Some scientists say we are just a few years away from creating drugs that delay or even prevent aging altogether. Still, the life-extension community has been excited about senolytic therapies for many years. More recently, scientific studies and early human trials reveal a growing number of compounds proven to increase healthspan. RELATED: How to Measure Your Immunological Age and Prevent Disease   Natural Senolytic Therapies You Can Take for Anti-aging A Background to Senolytic Therapies for Longevity Extending the human lifespan has a long tradition in many cultures. It has been the focus of the medical community, which continues to explore potential avenues in longevity. Senolytics, a medicine that selectively kills senescent cells (aging cells), is one such practice. Senescent cells are aged and malfunctioning cells that also affect normal cells and cause the body to become less capable of tissue repair. Inflammation control and protection against age-related diseases, cancer, or injury reduces, and the body becomes compromised. Individuals who amass more senescent cells seem to age quicker, and their biological clock ticks faster. Studies in mice found that by removing senescent cells, insulin resistance was alleviated, and cell dysfunction was improved. Many other animal studies have also recorded successful senolytic therapies.   Research There is now early evidence from human trials that confirm what the animal-based studies found about senolytic therapies as a way to improve life span. A 2019 report on how senolytics decrease senescent cells in humans used a combination of the senolytic leukemia drug dasatinib and the dietary supplement quercetin, previously shown to improve physical function in patients with idiopathic pulmonary fibrosis. In the new phase 1 trial, nine patients with diabetes-related chronic kidney disease were given the combination drugs for three days. Eleven days after the treatment had stopped, despite being completely eliminated from the system, the effects of the medicine appeared to last, and there was a significant reduction in the number of senescent cells. In another study, preclinical tests on the small molecule inhibitor UBX1325 showed it to eliminate senescent cells for patients with diabetic macular edema. This resulted in a positive impact on inflammation, reduction in vascular leakage, and improvement in retinal and visual function. The first phase of clinical trials is due to complete by October 2021.   Natural Senolytics A diverse variety of compounds, ranging from chemotherapy drugs to common dietary supplements, have been shown to have senolytic effects. You may have heard of the natural compounds ashwagandha, spirulina, and garlic extract, which are not strictly senolytics but can naturally increase killer cell activity and indirectly kill senescent cells. Some of the most powerful natural senolytics currently being studied and trialed include:   Fisetin Fisetin is one of the most potent senolytics. This flavenoid and natural yellow coloring agent is found in fruits and vegetables like apple, cucumber, persimmon, onion, and strawberry. The study of senolytic therapies on mice has been successful, demonstrating fisetin to have neurotrophic, anticarcinogenic, anti-inflammatory benefits, reduce senescent markers in tissues, reduce the risk of age-related diseases, and increase the risk of age-related diseases lifespan.   Quercetin Studies have shown this polyphenol to have a wide range of biological actions, including anti-inflammatory, anticarcinogenic, and antiviral activities and improving cardiovascular health. Due to recent studies, it is currently the most validated natural senolytics supplement.   Trans-Resveratrol This naturally occurring polyphenol is found in over 70 plant species and various human foods, notable grape skins. Evidence from animal and human studies reveals that the anti-inflammatory and antioxidant effects may prevent or act as a treatment against many non-communicable diseases such as neurodegenerative diseases, obesity, diabetes, cardiovascular diseases, and certain cancers.   Pterostilbene This natural dietary compound, the primary antioxidant component of blueberries, has increased bioavailability and demonstrated in multiple studies to have antioxidant effects. The preventative and therapeutic effects of pterostilbene have been connected to anti carcinogenesis, moderation of neurological disease, and improvement of diabetes, to name a few.   Curcumin Turmeric’s medicinal properties and the source of curcumin have been known for thousands of years. Anti-aging studies reveal that it aids in the management of inflammatory and oxidative conditions, as well as arthritis, anxiety, and high cholesterol. It has also been shown to help manage muscle soreness induced by exercise, therefore aids in the recovery and performance of athletes and active people.   Senolytic Complex for Longer Life The Senolytic Complex from Peak Human is a healthy aging support supplement that optimizes body function, protects from cell damage, and optimizes brain function. It contains all five of the above ingredients giving you the power to enhance your health. Senolytic therapies may provide an adequate treatment scope for a range of age-related diseases such as cancer, chronic kidney disease, and neurodegenerative disorders, which place a marked burden on healthcare systems worldwide. This field is still new, but early clinical trials are promising. If you have questions about senolytic therapies or any of the conditions discussed here, connect with us and learn more.   At Peak Human, our team of healthcare professionals is dedicated to helping you reach your ‘peak’ health with a custom whole-person approach. Using the most cutting-edge, science-backed biohacking and aesthetic tools, technologies, and treatments available today, we help you achieve the highest physical/cognitive performance state, leading to an improved overall quality of life. For questions or to book an appointment, don’t hesitate to contact us. Get personalized support and insight from expert physicians. Up Next: What Foods are Best for Your Health? A Treatment to Enhance Your Pelvic/Sexual Health DNA Genetic Testing – Worth it?

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