Peak Human

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Aging

Biological Age Test: Know Your True Age and Reverse the Clock

Overview Can you imagine living over 100 years in a future world with advanced medical technology? Biological age has captured growing attention from the scientific community and the general population due to its potential implications for extending youthfulness. As interest in this new health indicator surges, the concept of biological age testing has become a sought-after topic. People are eager to use these tests to gain insights into their aging journey and understand how their lifestyle choices impact their biological age. So what is a biological age test, exactly? And how, by unraveling the mysteries of our actual age, can researchers pave the way for interventions that promote longevity?   Time May Not Tell Your Real Age | Biological Age Test as a Better Health Indicator How Old Are You, Exactly? The Aging Disparity Why do some people not seem to age, ever? As I wondered about the curious phenomenon of age-defying individuals like celebrities and biohackers, it became clear that the passage of time is not always an accurate indicator of a person’s health. Indeed, each person’s aging process is unique due to many factors that co-influence our pace of reaching the later stages of life. While most people appear age-appropriate, some look younger (or older) than their chronological age, as indicated in their IDs. You’re right. Biological age can vary significantly from chronological age. In other words, they do not always align with each other.   The Aging Factors Lifestyle choices are vital, with factors such as diet, exercise, and stress management affecting the body’s cellular and overall health. Regular physical activity can keep our heart robust, muscles strong, and joints agile, contributing to increased longevity. A well-balanced diet rich in nutrients can combat oxidative stress and inflammation, both associated with aging. Meanwhile, stress management techniques like meditation can reduce the impact of psychological stress, which can otherwise accelerate aging. Of course, genetics play a significant role in how we age. Some individuals may have inherited advantageous genetic variations that protect against age-related diseases and slow aging. In contrast, genetic predispositions can make some more susceptible to premature aging or age-related conditions.   What Is a Biological Age Test? A ‘Real Age’ Test Fortunately, in the pursuit of extending human life expectancy, numerous research labs have been diligently developing tools to determine how we age from within – the biological age test, also known as the real age test. This cutting-edge assessment goes beyond chronological age and delves into the intricate molecular processes that shape our aging trajectory. One of the most crucial factors influencing our aging is gene expression, which refers to how our genes are activated or silenced in response to internal and external stimuli. Over time, environmental factors, lifestyle choices, and other influences can lead to alterations in gene expression, impacting the overall aging process.   Epigenetic Clocks Two significant measures (known as epigenetic clocks) that have gained relevance in biological age testing are PhenoAge and GrimAge: PhenoAge: evaluates a comprehensive set of aging-related biomarkers to estimate an individual’s biological age accurately. This sophisticated assessment considers various blood-based markers, including C-reactive protein, albumin, and hemoglobin, to provide insights into overall health and aging status. GrimAge: goes further by incorporating DNA methylation patterns into its analysis. DNA methylation is an epigenetic modification that influences gene expression. GrimAge utilizes these patterns to assess an individual’s risk of age-related diseases, providing a bigger picture of their biological age.   How Does a Biological Age Test Work? Testing Procedure A typical procedure involves the user providing a sample of their biological material, either a saliva or blood sample, which contains essential genetic information that allows experts to analyze epigenetic modifications through gene expression patterns. Once the sample is collected, it undergoes a comprehensive analysis. The data is then compared to a vast reference database of biological age markers. This comparison allows experts to estimate the individual’s biological age accurately. The results can be presented as a numerical value or through a graphical representation, illustrating how the biological age compares to the traditional chronological age. The final report generated from the test includes the person’s biological age and may offer personalized recommendations to promote healthy aging. These often revolve around lifestyle changes that can positively impact gene expression and aging.   Some Popular Tests One example of biological age tests is the myDNAge test kit, built upon Dr. Steve Horvath’s epigenetic clock. Based on cutting-edge Next-Generation Sequencing Technology, the test scans over 2,000 biomarkers in the human genome, susceptible to epigenetic changes. By analyzing these markers, it accurately calculates an individual’s biological age. Some other biological age tests that are currently available include the following: NOVOS Age by Novos Labs Index by Elysium Health TallyAge by Tally Health TruAge COMPLETE by TruDiagnostic   What Does a Biological Age Test Result Mean to You? More Than a Number The significance of a biological age test extends far beyond simply informing individuals of a number representing their actual age. It is a powerful tool enabling experts to map out a comprehensive action plan, addressing various aspects of a person’s health to optimize well-being and increase lifespan. For instance, the myDNAge test report goes beyond revealing biological age and offers a tailored improvement plan. This plan incorporates beneficial practices related to nutrition, lifestyle modifications, stress and weight management, and physical activity.   Proactive Measures By implementing the recommendations provided by the myDNAge test report, individuals can proactively address health concerns and change their daily routines. Moreover, the biological age test report highlights specific biomarkers for overall health. Understanding the status of these biomarkers empowers individuals to take targeted actions to maintain them at optimal levels.   What Can Affect Your Biological Age Test Result? Various factors can negatively influence a person’s biological age test result. Understanding these elements is crucial to make informed decisions about health and well-being. Factors negatively affecting a biological age test result include the following: Sedentary Lifestyle: Lack of physical activity accelerates aging processes and raises biological age.

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Health

Grip Strength and Longevity: What the Power of Your Hands Means for Overall Health

Overview Although often overlooked, grip strength is a vital indicator of overall health. As the hands are involved in most physical tasks, weakness in this area can signify something is amiss. Research has linked low grip strength to health issues such as poor mobility, increased risk of falls, and diseases. Also, grip strength has been associated with markers of age-related diseases, including bone loss and frailty. For this reason, recognizing how much grip strength a person has can help identify potential health concerns early on and provide insights into their overall well-being. This article explains how grip strength and longevity have strong associations, what this measurement means to a person’s overall health, how doctors can utilize it to enhance healthcare outcomes, and, most importantly, how to improve grip strength.   Research Claims Grip Strength as a Stand-alone Predictive Biomarker for Longevity What Is Grip Strength? And How Is It Measured? Grip strength refers to the muscular strength of an individual’s hands and forearms and the ability to hold objects securely. In terms of physics, it is a measure of the maximum force that can be generated by the muscles involved in gripping tasks. The grip strength test is a standard method to assess grip strength, which uses a hydraulic or digital dynamometer. A dynamometer measures the force exerted by the hand when squeezing the instrument. The individual holds the dynamometer in their hand and squeezes it as hard as possible. The device then measures the amount of force applied, quantifying grip strength.   Average Grip Strength by Age: Know Your Power Age Range Average Grip Strength (Men) Average Grip Strength (Women) Achievable Tasks 20-29 85-105 lbs 50-70 lbs Writing, typing, opening jars 30-39 80-100 lbs 45-65 lbs Carrying groceries, using tools 40-49 75-95 lbs 40-60 lbs Lifting moderate weights, gardening 50-59 70-90 lbs 35-55 lbs Operating power tools, DIY projects 60-69 65-85 lbs 30-50 lbs Opening bottles, household chores 70+ 60-80 lbs 25-45 lbs Turning door knobs, light tasks *Grip strength averages can vary depending on fitness level, hand dominance, and overall health. The achievable tasks are general examples and may vary from person to person based on their specific needs and physical abilities.   What Does Grip Strength Mean for Your Health? Grip Strength and Bone Density, Fractures, and Falls Research consistently demonstrates a relationship between grip strength and bone mineral density (BMD) and osteoporosis at various sites involved in hand grip. Grip strength has also been associated with hip fractures and increased risk of fragility fractures. Furthermore, grip strength is related to falls, which are a key cause of fractures. Studies have shown that individuals with lower grip strength have a higher incidence of falls than those with stronger grip strength. Longitudinal studies have explored the predictive value of grip strength and have found it to be associated with incident fractures, even when accounting for other factors such as lifestyle and body size. In older adults, reduced grip strength and knee extension strength have been significantly related to fall-related fractures, with the former being a better measurement. Grip strength has been suggested as a cost-effective predictor of fractures, particularly when measuring BMD is impractical. Tests of sit-to-stand performance, walking time, and grip strength have shown predictive value for falls and recurrent falls.   Grip Strength and Nutritional Status Grip strength has been explored as a potential biomarker for assessing nutritional status in various patient populations, yielding mixed results. Lower grip strength has been associated with an increased risk of malnutrition among older Chinese inpatients, as measured by Nutritional Risk Screening and Subjective Global Assessment tools. In patients undergoing hemodialysis, grip strength showed significant inverse correlations with the Malnutrition-Inflammation Score, regardless of race, age, and gender. Meanwhile, patients with gastrointestinal cancer and refractory cachexia had the lowest grip strength, suggesting a relationship between cachexia severity and grip strength. However, more than grip strength alone was required to confirm malnutrition in older patients, as it needed better validity as a single nutrition indicator. Nonetheless, grip strength assessments were more widely completed than other functional measures (92%), such as the 5-meter walk test (43%), indicating that grip strength may be more useful in contexts where other measurements are impractical.   Grip Strength and Disease Status and Comorbidity In individuals with diabetes, weakness in the lower limbs is commonly observed, particularly in the presence of neuropathy. However, limited grip strength has also been reported in individuals with diabetes or prediabetes, and it has been inversely related to measures of glucose control, such as fasting glucose and HBA1c, and systemic inflammation. Grip strength has also been shown to be related to multimorbidity, regardless of whether diabetes is part of the comorbidity load. Grip strength can also predict disease and disease-specific mortality, especially cardiovascular disease and cancer. Specifically, decreased grip strength has been associated with an increased risk of cardiovascular disease, and it is a powerful predictor of cardiovascular and all-cause mortality, surpassing the predictive value of systolic blood pressure. Grip strength is also linked to myocardial infarction and stroke (hazard ratio 1.07 and 1.09, respectively).   Grip Strength and Cognition, Depression, and Sleep In older adults, significant relationships have been observed between grip strength and cognitive function, including measures such as the Mini-Mental State Examination, information processing speed, executive functioning, and memory tasks. Longitudinal studies examining grip strength and cognitive function have yielded mixed results, with some studies suggesting an association between grip strength and cognitive decline over time, while others find limited evidence for such a relationship. Grip strength has also been linked to depression, with weaker grip strength being associated with higher prevalence rates of depression (8.8% among adults classified as weak compared to 3.8% among those considered normal) in various countries. However, this correlation may vary based on factors such as income levels. Meanwhile, lower grip strength is also related to greater sleep impairment, lower sleep quality, and longer sleep duration. This effect on sleep may be one factor that concurrently results in a lower quality of life.  

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Biohacks

Jumpstart Weight Loss With Biohacking, Nutraceuticals, and Plant-based Supplements

Overview For years, we have long known that incorporating healthy habits, including regular exercise routines and nutritional meal plans and diets, into our daily life is critical for repairing, refueling, and optimizing our bodies. According to health experts and scientists, what you eat or your nutrition intake may significantly contribute to a healthy weight. We can better control our body weight and promote overall wellness and well-being through proper nourishment. However, there lies an obstacle: today’s fast-paced lifestyle prevents people from meeting the recommended nutrition, characterized by skipping meals or resorting to processed or fast foods with little to no nutritional value. This often leads to poor nutrition or nutrient deficiencies, impairing bodily functions and processes. Approximately 33 identified food supplements and substances have been proven to have a wealth of positive impacts on weight loss, such as improving immune function, protecting against pathogens and harmful gut bacteria, enhancing nutrient absorption, modulating energy expenditure, and improving the metabolic system.   Jumpstart Weight Loss with Nutraceuticals and Plant-based Supplements Weight-Loss Supplements: How Effective Is It? By definition, as a result of an imbalance in calorie intake and output, overweight and obesity encompass the disease of individuals with body mass index (BMI) ranging from 30 to 40, or even higher, determined by dividing their body weight (kilograms) by their height (meters). Over the decades, the disease has escalated into a global epidemic that poses ripple threats to the health of over 1 billion people. It affects vital organs like the heart, lungs, kidneys, and liver, putting those affected at an increased risk of developing critical, chronic health conditions, most notably diabetes, stroke, heart disease, cancers, and mental health issues. Uncontrolled or excessive calorie consumption stands out as one of the fundamental causes of obesity or being overweight, fueled by the dominance of calorie-dense food in daily life. Many studies have shown that a sedentary lifestyle where people are rarely active is also responsible for a higher risk of obesity. Amidst the ongoing global health crisis, weight-loss devotees seek effective measures to manage their weight. Although physical activity and a healthy diet are typically recommended for maintaining a slim figure, many people believe over-the-counter (OTC) weight loss supplements could be the answer to their journey of shedding extra pounds. However, it is essential to note that while OTC supplements that claim weight loss might help with speeding up the process, they are not regulated by the Food and Drug Administration (FDA), fueled by the fact that not many clinical studies further support the efficacy of supplements in weight loss. It likely means taking weight loss supplements without consulting a doctor beforehand or taking precautions is unsafe. Due to the widespread ingredient mislabeling, these supplements may inflict undesirable side effects or clashes between other supplements and prescriptions, as you might not exactly know what you are getting in the bottle.   What Are Nutraceuticals and Plant-based Supplements? With more effort in nutrition research looking for advanced methods to help lose weight, nutraceuticals and plant-based supplements have grabbed great attention from people seeking sustainable practices to remove excess weight. Coined by Stephen DeFelice in 1989 from “Nutrition” and “Pharmaceuticals,” nutraceuticals refer to non-specific biological therapies and products derived from natural sources that fuel the body with nutritional and medicinal values. These substances are based on the strong belief that daily food is an abundant source of healing properties that can help promote wellness, fend off diseases, and alleviate symptoms of illnesses. Nutraceuticals, or functional foods or phytochemicals, are classified into a wide range of dietary products for diverse wellness purposes, such as dietary supplements, multivitamins, diets, fortified foods, probiotics, and genetically engineered foods. While nutraceuticals are thought to be an innovative approach to invigorating health and wellness with the rise of liquid, capsules, or pill-based dietary supplements, harnessing medicinal and therapeutic benefits from foods is not a new concept. World-renowned ancient civilizations like China, Egypt, and India have recognized the potential of certain natural foods in preventing and treating diseases. Across different cultures, a strong emphasis is on eating a wholesome diet to achieve good health.   8 Nutraceutical and Plant-based Supplements for Jumpstarting Weight Loss Below are the 8 most commonly used nutraceutical and plant-based supplements for weight loss, ranging from controlling appetite and boosting nutrient absorption to modulating energy expenditure and speeding up fat metabolism.   Green Tea Extract Besides being a popular beverage enjoyed by millions worldwide, green tea has been presented in Chinese medicine and other civilizations as a holistic treatment for various health concerns due to its high concentration of antioxidant and anti-inflammatory properties. How can green tea extract help with weight loss? Green tea contains beneficial substances that may help you lose weight faster — during exercising and at rest. Caffeine and EGCG (Epigallocatechin gallate) have been proven to help burn calories, raise metabolic rate, and improve exercise performance. Catechins, another potent antioxidant found exclusively in green tea, play a significant role in weight loss since it boosts norepinephrine activity. This hormone helps the body resolve body fat more efficiently. Modulating gut microbiota is another benefit of green tea extract in assisting weight loss. Although green tea is generally safe, be cautious if you are sensitive to caffeine. Side effects, including bloating, agitation, insomnia, and dizziness, can arise when consuming green tea long term.   Protein Protein is an essential nutrient for a better-looking body, reflected by many workout enthusiasts increasing their protein intake with protein shakes and high-protein diets to shed weight and belly fat. One of the most significant benefits of protein in weight loss is suppressing hunger. This nutrient has been shown to have the ability to reduce the hunger hormone ghrelin while boosting the levels of satiety hormones like peptide YY, GLP-1, and cholecystokinin. As a result, you may feel less hungry, hence lower calorie intake due to fewer meals.   Chitosan Chitosan comes from the hard outer layer of shellfish like crabs, lobsters, shrimp, and prawns. When it comes to weight loss, much

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Biohacks

Epigenetic Inheritance: Can We Pass Our Experiences to Future Generations?

Overview Ever wondered if our genes alone determine who we are? Well, there’s more to the story! Since the groundbreaking sequencing of the human genome, the buzz around “epigenetics” has grown. It suggests that our daily choices, like what we eat, the air we breathe, and even our emotions, might impact not only our genes but also those of future generations. While we know the environment can affect gene expression and lead to diseases, the long-lasting effects on future descendants are still a puzzle. And although epigenetic inheritance has been observed in plants, its contribution to humans is uncertain. This article explores the current research on epigenetic inheritance and delves into the captivating realm of inherited traits beyond DNA.   Future Generations May Have Epigenetic Traits of Their Parents’ Experiences What Is Epigenetic Inheritance? Epigenetics refers to the modifications in the gene expression profile of a cell that are not caused by changes in the DNA sequence itself. Environmental exposures, lifestyle choices, and developmental processes can influence these modifications. Epigenetic changes can alter how genes are “read” and expressed, affecting cellular functions and impacting an organism’s traits. Thus, epigenetic inheritance refers to the transmission of specific epigenetic marks from one generation to the next. There are two main types of epigenetic inheritance: intergenerational epigenetic inheritance and transgenerational epigenetic inheritance. Intergenerational epigenetic inheritance: involves the transmission of epigenetic marks from parents to their offspring. The epigenetic marks acquired during an individual’s lifetime can be passed on to their children, influencing their development. Transgenerational epigenetic inheritance: goes beyond the direct parent-offspring relationship. It refers to the transmission of epigenetic information from grandparents to their grandchildren, bypassing the immediate offspring.   According to the classical definition, environmental triggers experienced by a pregnant female (F0) can impact not only the first new generation (F1) but also its germ cells, which represent the second generation (F2). As a result, changes in the third generation (F3) can be attributed solely to epigenetic inheritance.   How Does Epigenetic Inheritance Occur? Direct Epigenetics Direct epigenetics (DE) refers to the changes in gene expression during a person’s lifetime. It involves the action of special proteins called transcription factors that can quickly control how genes are activated or silenced. These factors are crucial in triggering a chain reaction of events that can have lasting effects. Immediate-early genes are responsible for producing these regulatory proteins. Non-coding RNAs (ncRNAs) are also involved in epigenetic processes, although there is an ongoing debate about whether they should be considered part of epigenetics. The early stages of life, especially the first few months, are critical in shaping an individual’s development. Experiences during this time can leave a lasting imprint on gene expression and may influence mental health later in life.   Indirect Epigenetics Indirect epigenetics (IE) is another way epigenetic inheritance occurs. It exists in two subcategories: within indirect epigenetics (WIE) and across indirect epigenetics (AIE). WIE refers to the epigenetic changes that happen while the individual develops synchronously. It starts when the zygote is formed, and factors during gestation can indirectly influence the developing individual. AIE transmits epigenetic changes from parents to offspring, even across generations. It involves the influence of the parents’ and grandparents’ earlier life experiences, which can affect the composition of germ cells and the intrauterine environment.   Certain events closer to conception may have stronger predictive power, but even distal events can play a role. These changes are asynchronous and can have long-lasting effects on the offspring’s development later in life.   What Are the Examples of Epigenetic Inheritance? Animal Models Epigenetic inheritance is supported by several lines of evidence from animal studies. One example is the impact of maternal behavior on offspring. Specifically, the quality of maternal care can predict alterations in DNA methylation patterns in the offspring. For example, mothers’ behaviors like licking, grooming, and nursing can change DNA methylation, particularly in genes related to the stress response. Meanwhile, early-life stress, such as maternal separation, has also been associated with altered methylation patterns in genes implicated in anxiety. These findings suggest that environmental experiences can leave lasting epigenetic marks that influence future generations’ behavior and emotional well-being. Studies have also explored the effects of stress on specific genes, such as brain-derived neurotrophic factor (BDNF). The dysregulation of this gene has been linked to mental health disorders. Animal models of depression have shown downregulation of BDNF in certain brain areas, accompanied by changes in methylation patterns.   Clinical Evidence Evidence of epigenetic inheritance in humans can also be seen in studies on the effects of the maternal environment during pregnancy on offspring. For example, a lack of essential nutrients like protein, iron, or zinc can lead to cognitive deficits and even intellectual disabilities and autistic symptoms in the offspring. Meanwhile, smoking during pregnancy can result in premature birth and deficits in motor skills, memory, and behavior. Maternal stress, specifically excess cortisol due to anxiety, can also cause neurodevelopmental damage in the fetus. Compelling evidence from longitudinal studies also provides insights into indirect epigenetic inheritance. For instance, male children who experienced undernourishment in the womb during the Dutch famine of 1944-1945 and their offspring showed a higher risk of obesity, glucose intolerance, and coronary heart disease in adulthood. Transgenerational trauma has also been studied, focusing on the offspring of war survivors, combat veterans, and refugee families. A Norwegian longitudinal study on Vietnamese refugees revealed a heightened risk of mental disease in third-generation (F3) offspring when their grandparents were diagnosed with post-traumatic stress disorder upon arriving in Norway.   Can We Prevent Transgenerational Trauma? Environmental enrichment (EE), which provides cognitive stimulation and physical activity, has been found to modify behaviors and reduce stress responses in adult rodents. An experiment used adult male mice to explore the transgenerational effects of paternal EE. Some mice were exposed to EE, while others were housed under standard conditions. After 4 weeks, they were mated, and their F1 generation was used to produce the F2. The F1 and F2 offspring were then tested for anxiety

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Health

What Is Chelation Therapy? Important Risk Factors You Need to Know

Overview Have you ever heard of chelation therapy? It’s the treatment of choice proven to treat conditions related to heavy metal toxicity. Yet, despite its effectiveness, chelation therapy is often overlooked and underappreciated. Many people falsely believe that the human body can get rid of heavy metals on its own, but the truth is that heavy metal toxicity is a serious and prevalent problem. According to the World Health Organization (WHO), millions of people worldwide are affected by heavy metal poisoning annually – a “burden of disease,” as the health agency calls heavy metal poisoning. This affliction is especially true for those regularly exposed to heavy metals, such as industrial workers and people who live near polluted areas. In 2019, lead poisoning alone was responsible for half of the 2 million lives lost due to chemicals. At the end of the day, although chelation therapy is a brilliant way to remove toxins from the body, raising awareness about this treatment is crucial so that more people can benefit from its life-changing effects. This article discusses chelation therapy, its mechanism of action, application techniques, benefits, and the risk factors you should know before starting a heavy metal detox.   Heavy Metal Detox: How Chelation Therapy Can Be an Antidote to Your Body and Mind What Is Chelation Therapy? Chelation therapy is a medical treatment involving chelating agents to remove heavy metals from the body, such as: Lead Arsenic Cadmium Thallium Mercury   Heavy metal toxicity is a severe health concern from exposure to various sources, such as contaminated air, water, food, and medical treatments. While the human body can get rid of harmful chemicals on its own, the amount removed may not be sufficient, leading to the accumulation of toxic substances in the system. Chelation therapy has been used to treat heavy metal toxicity for decades. Yet, it is also a part of treating other conditions, such as cardiovascular and neurodegenerative diseases. Despite the effectiveness of chelation therapy, many people are unaware of its benefits, and some still believe that the human body can get rid of heavy metals on its own. Unfortunately, this misconception is extremely dangerous as heavy metal toxicity still exists no matter how hard our body tries to keep itself healthy.   How Does Chelation Therapy Work? Chelation therapy uses chelating agents to remove metals from the body and restore health. Chelating agents are organic or inorganic substances that can bind to metal ions, forming a complex that can be easily eliminated from the body through the excretory system. The most common chelating agents are: EDTA (ethylenediamine-tetraacetic acid) DMSA (dimercaptosuccinic acid)   During the therapy, the chelating agent is administered into the body either intravenously (into a vein) or orally. Once inside the body, the chelating agent travels through the bloodstream, binding to heavy metals and forming a complex. This complex is then eliminated from the body primarily through urine. Chelation therapy can take several sessions, depending on the severity of the heavy metal toxicity. For example, 20 to 40 sessions are typically necessary for EDTA chelation therapy. Each session may last from 30 minutes to several hours.   Types of Chelating Agents Used in Therapy EDTA and DMSA are the two primary chelating agents used in chelation therapy. While they have similar mechanisms of action, some differences exist regarding their benefits, uses, and conditions they can treat.   EDTA Chelation Therapy EDTA is a polycarboxylic amino acid that binds to heavy metals, including lead and mercury. It is administered intravenously and can remove heavy metals from the bloodstream. Besides treating heavy metal toxicity, EDTA is effective in atherosclerosis, a condition where plaque builds up inside the arteries.   DMSA Chelation Therapy DMSA is a sulfhydryl-containing compound. DMSA’s hydrophilic nature results in significant absorption in the gastrointestinal tract, hence administered orally. It can remove mercury, cadmium, and arsenic and is often used to treat lead poisoning in children. DMSA is also used in the treatment of autism.   Which Is Better? While EDTA and DMSA are equally effective chelating agents used in various heavy metal poisoning conditions, their uses and benefits differ. EDTA is more effective at removing heavy metals from the bloodstream and is often used to treat cardiovascular conditions. Meanwhile, DMSA can also remove heavy metals from the body but must be taken shortly after exposure to avoid accumulation and toxicity. Therefore, it is crucial to consult a qualified healthcare provider to determine which chelating agent is best for each case.   How Is Chelation Therapy Applied? The procedure involves several steps, varying depending on the chelating agent used and the condition being treated. Below is a step-by-step procedure for chelation therapy: Initial consultation: The patient meets with a healthcare provider to discuss their symptoms, medical history, and previous exposure to heavy metals. Diagnosis and assessment: The healthcare provider may perform a blood test or other diagnostic tests to assess the patient’s level of heavy metal toxicity. Chelating agent administration: Depending on the specific chelating agent used, it may be administered intravenously or orally. Monitoring: The patient is closely monitored throughout the chelation therapy session, which may take 30 minutes to several hours. Repeat sessions: Depending on the severity of the heavy metal toxicity, the patient may undergo several sessions, typically once a week. Follow-up: Patients may undergo follow-up diagnostic tests after the chelation therapy sessions to assess their condition.   Proven Benefits of Chelation Therapy Heavy Metal Toxicity According to research, fundamental principles of metal poisoning treatment deal with a step-by-step methodology, which is as follows: Prevention of further metal absorption into the system Elimination of metal from the circulation Inactivation of metal bioavailable in the system   Research also indicates that metal poisoning can be acute or chronic. Symptoms of acute poisoning are often evident, recognizable, and immediately treatable. However, chronic metal toxicities may be poorly described as general illnesses and not identifiable as any conventional disease. Moreover, chronic toxicities may be irreversible, causing delayed or undetectable development of other conditions, like

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Health

How Does Dehydration Affect the Physical and Cognitive Performance of Athletes?

Overview Did you know that our bodies are 75% water? Water isn’t just a thirst quencher. It’s a life-giver. For athletes, water is their secret weapon. Why? Muscles are a crucial part that fuels an athlete’s performance. And guess how much water there is in the muscles? It’s also 75%. Not only does water help athletes perform at their peak, but it also prevents dehydration, which can seriously impact their performance. That’s why staying hydrated is vital! Meanwhile, dehydration causes a decrease in blood volume, which means less oxygen gets to the muscles. And that’s when the cramps and fatigue kick in, making it impossible for athletes to give their best performance. Not to mention the cognitive impairment dehydration can cause, resulting in confusion, irritability, and a lack of focus. This article discusses the importance of water for athletes who require regular fluid intake to compensate for their massive water loss level, explains exercise-induced dehydration, and shows how to prevent dehydration before, during, and after exercise.   Stay Hydrated, Athletes! Learn the Impact of Dehydration on Performance What Happens When We Exercise? When we exercise, our bodies undergo a series of physiological changes to meet the demands of physical activity. Our muscles require more energy, supplied by the breakdown of glucose and fats. This process increases the production of carbon dioxide (CO2) and heat, causing our body’s temperature to rise. If the body reaches its heat limit, meaning the temperature continuing to increase will cause overheating, it needs to cool off through perspiration. Sweating or perspiration is the body’s way of regulating its temperature. Sweat glands all over the body release a liquid mixture of water, salt, and electrolytes onto the skin’s surface. As the sweat evaporates, it carries away heat and lowers the body’s temperature. However, excessive sweating can cause dehydration, leading to various problems. Dehydration happens when the body loses more fluid than it consumes. This phenomenon can occur when we don’t drink enough water, especially during and after prolonged or intense exercise. Dehydration causes fatigue, muscle cramps, dizziness, and even heat stroke or heat exhaustion, which can be life-threatening.   What Does Exercise-induced Dehydration Mean? One of the most predominant targets of dehydration is athletes, who lose a massive amount of fluid due to intense physical activity. This event is called exercise-induced dehydration, typically occurring during and after training. According to the American College of Sports Medicine, a water loss of only 2% of body weight can result in dehydration, significantly affecting performance and increasing the risk of heat exhaustion or heat stroke. Exercise-induced dehydration is a common problem, with research indicating that up to 28% of Americans experience some degree of dehydration during workouts, making it a frequent cause of hospital admission. Also, a study published in the Journal of Athletic Training found that college athletes had a high prevalence of dehydration, with 20% of male and 34% of female athletes experiencing it during practice or competition. Professional athletes are particularly vulnerable to exercise-induced dehydration, as their intense training regimens and competition schedules require them to perform at their highest levels under physical stress. As a result, athletes must be aware of the risks of dehydration and take appropriate measures to prevent it. In other words, dehydration prevention strategies should be critical to every training regimen and competition schedule.   How Do You Know You Are Dehydrated? Paying attention to the signs and symptoms of dehydration is equal to preventing serious health risks. Monitoring your urine color is the easiest way to tell if you’re dehydrated. For example, dehydration occurs if your urine is dark yellow or amber-colored. Other signs and symptoms of dehydration during exercise include: Thirst: Feeling thirsty is the body’s way of telling you it needs more water. Dryness: You may experience a dry mouth and throat when dehydrated. Fatigue: Dehydration can cause fatigue, weakness, and dizziness. Headache: Dehydration can cause a headache, which may worsen with movement. Muscle cramps: Dehydration can cause muscle cramps in the legs and arms. Nausea and vomiting: Dehydration can cause nausea and vomiting, especially during intense exercise. Rapid heartbeat and breathing: When dehydrated, your heart may beat faster, and your breathing may become shallow. Dark circles under the eyes: Dehydration can cause dark circles under the eyes. Reduced urine output: Dehydration can reduce urine output, which may be darker when urinating.   How Does Dehydration Affect Performance? Physical Performance Studies have shown that even mild dehydration can lead to decreased physical performance and an increased risk of injury among athletes. A study published in the Journal of Athletic Training found that dehydration negatively impacted the performance of college athletes during practices and games. The study showed that dehydrated athletes had a higher heart rate (extra 3 to 5 beats per minute for every 1% body weight loss due to water loss), increased fatigue, lower cardiac output and arterial pressure, and lower overall performance than hydrated athletes. Another study published in Nutrition Reviews found that dehydrated endurance athletes, in the range of 2.6% to 5.6% body weight, experienced a decrease in short-duration (5 to 30 minutes) and high-intensity exercise performance. The study also discovered that, over a threshold of 3.1%, each percent loss in body weight results in a 2.9% reduction in maximal oxygen use. Moreover, a 2.3% pre-exercise body weight drop reduced time-trial running performance compared to a hydrated condition.   Cognitive Performance According to research, the severity of dehydration may influence how badly cognitive function is affected. For example, women’s mood characteristics, including vigor, alertness, tiredness, calmness, confusion, and happiness, are significantly impacted during water deprivation. Also, children drinking insufficient water may experience temporary cognitive decline. Meanwhile, increased water consumption has been linked to improved visual attentiveness and short-term memory in long-distance runners and walkers. However, the bigger problem is that only a 2% loss of a person’s body weight is enough to cause all those impairments to human cognition. For a 150-pound person, this amount corresponds to a body weight loss of 3 lbs,

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Biohacks

Understanding How Biohacking Works for Weight Loss

Overview Biohacking has increasingly become a buzzword that attracts massive attention from the medical community and general fitness enthusiasts. While this term is usually associated with technically demanding practices that can only be performed in a lab while promising little to no tangible or measurable effectiveness, the biohacking world is blooming recently with more advanced techniques that address various health aspects. As a result, those constantly looking to improve their health and achieve peak performance may greatly benefit from the incredible and science-based shortcuts to optimal well-being. From biohacking the brain for elevated cognitive functions to biohacking the waistline for healthy body composition, this practice has reached beyond a fad trend to become a genuine game-changer in upgrading the quality of life. This article discusses the most commonly accepted definition of biohacking for weight loss and management, explains how biohacking works and provides the top-of-the-line techniques of biohacking that result in the most significant benefits.   Biohacking for Weight Loss – Learn Science-backed Shortcuts to Losing Weight What Is Biohacking for Weight Loss? Despite continuous medical science and technology development in the past several decades, the foundations for weight loss and management have remained unchanged: diet, exercise, and supplementation. However, scientists and fitness experts have constantly shown their endeavor to condense the weight loss process through strategies and approaches that target the human body in a way that is unprecedented in history. One of the most prevalent examples of this unwavering attempt to manipulate weight loss is the invention of the Vasper biohack technology by Vasper Systems. This fitness device claims that users can reap the benefits of 2 hours of intense exercise in only 21 minutes of low-intensity exercise. While this result seems too good to be true, the Vasper technology is a product of combined science and technology. Surprisingly, the secret behind the scene is nothing more than compression, circulation, and cooling; all together at once. That is to say, biohacking for weight loss, in the most accurate definition, is the practice of inducing weight loss in a non-traditional way by addressing the usually ignored aspects of human health regarding weight loss, such as hormones or metabolism. Traditionally, whether weight loss comes down to being successful or not is associated with how many calories a person burns or how much food is consumed. However, what if we can still induce weight loss effectively while taking away all or most of the work that is usually the cause of failing adherence or sustainability? The Vasper technology mentioned above shortens the duration of a workout by almost 6 times, from 120 to just 21 minutes, which can offer a mighty leap toward sustainable weight loss.   Losing weight using the Vasper technology can be a game-changer to biohack weight loss – Source: Channel 4 Entertainment.   How Does Biohacking for Weight Loss Work? Until now, there has been no limitation regarding the mechanism of actions of biohacking for weight loss. It is because each method considered biohacking works differently, and therefore, giving an all-in-one formula for biohacking appears infeasible. For example, the Vasper technology leverages the combination of compression on the major muscle groups in the body, circulation of the endocrine system, and cooling for oxygenation and recovery to result in peak performance at the expense of little effort. Another similar biohacking approach is the implantation of microchips into the body to track diet and sleep patterns. Given that how we eat and sleep tremendously affect weight loss, it makes sense when someone puts every body activity into a measurement. Biohacking for weight loss also involves optimizing your diet by focusing on nutrient-dense, whole foods low in sugar and processed carbs. This optimization can help regulate blood sugar levels, reduce inflammation, and promote weight loss. Also, eating balanced macronutrients, including carbohydrates, protein, and fat, can help regulate hormones, reduce cravings, and promote weight loss. Many may ignore the importance of hormones in weight loss. The truth is the other way around. Hormones are essential because they regulate various processes in the body that can impact your ability to lose weight. For example, when you eat carbs, your body releases insulin to move glucose away from your blood. High insulin levels can lead to insulin resistance, contributing to weight gain and other health issues.   Benefits of Biohacking for Weight Loss Less Effort, More Benefits You can benefit from whatever techniques and strategies you are implementing, like diet, exercise, and supplementation, while making the weight loss process simpler and more manageable with biohacking. By utilizing cutting-edge technology, biohacking can help individuals reach their weight loss goals faster and more efficiently than traditional methods. In addition, biohacking can eliminate the need for strenuous exercise routines or restrictive diets, making it easier for individuals to incorporate weight loss practices into their daily lives. So by taking advantage of the benefits of biohacking, you can achieve your weight loss goals without sacrificing your time, energy, or enjoyment of life.   Take Body Under Control Biohacking for weight loss also allows you to manipulate your fitness journey and goals by understanding your body’s unique needs and characteristics. With technology and data-driven approaches, biohacking can also help you identify the underlying factors contributing to your weight gain and tailor your weight loss strategies accordingly. This approach can help you identify what works for your body and what does not, allowing you to make informed decisions about your health at the right time. For example, suppose you constantly measure your blood sugar levels and notice that they always spike after a meal. In that case, it is the right time to reduce the sugar and carbs portion. Remember that high blood sugar and insulin do not manifest on the surface of your body, and using specific tools to track and analyze is the only way to have such information.   Biohacking Techniques for Weight Loss Intermittent Fasting and Fasted Exercise Intermittent fasting and fasted exercise are two popular biohacking techniques for weight loss that can help

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Health

Metabolic Benefits of Exercise: How Building Muscle Can Help You Burn More Calories

Overview When it comes to the topic of weight loss, most people tend to fixate on shedding excess fat rather than focusing on building muscle. We yearn for leaner bodies, envisioning a future where fat stores vanish and we emerge with a slender physique. However, it’s time to unveil the truth: we tend to be under-muscled rather than over-fat. In our quest for weight management, we often overlook the role of muscle mass in our metabolic health. Building muscle enhances strength and physical performance and ignites a cascade of metabolic benefits. Therefore, increasing our muscle mass can boost our body’s ability to burn fat and maintain a healthy weight. In this article, we delve into the remarkable metabolic benefits of exercise and shed light on its profound impact on our overall metabolism. We’ll also explore how building muscle is the key to increased calorie burn and achieving long-term weight management success.   Fueling Your Calorie-burning Engine: Exploring the Metabolic Benefits of Exercise The Science Behind Calorie Burning Understanding Basal Metabolic Rate (BMR) Contrary to a widespread misconception, the total calorie intake does not solely determine the energy a person needs to burn to maintain a calorie balance. Even at rest, our bodies continue to burn many calories. This energy expenditure is known as Basal Metabolic Rate (BMR) or Resting Metabolic Rate (RMR) and can contribute to at least 60% of our total calorie expenditure (TEE). Surprisingly, physical activities only account for around 30% of TEE. In comparison, the remaining 10% is allocated to the energy required for digestion and absorption of food, a process referred to as diet-induced thermogenesis. Understanding the significance of BMR/RMR sheds light on how our bodies constantly utilize energy, even during rest periods. This basal metabolic activity is essential for maintaining vital bodily functions such as breathing (5-10% of TEE), circulating blood (3-4%), regulating body temperature (5-10%), and supporting organ function (20-25%).   Exercise and Total Energy Expenditure (TEE) Although we naturally burn a significant amount of energy as BMR/RMR, many individuals consume more calories than they need, especially when regular exercise is absent. This discrepancy from the ideal scenario where calorie intake matches BMR/RMR without physical activity can be attributed to various factors. Oversized portions, prevalent in packaged foods, contribute to consuming more calories per meal. The abundance of high-calorie foods, often rich in added sugars, unhealthy fats, and refined carbohydrates, can be irresistible, leading to overconsumption. Emotional eating and food cravings further disrupt calorie balance as individuals use food as a coping mechanism. Mindless eating, distractions while eating, social influences, and a lack of awareness regarding calorie content also contribute to excess calorie intake. By incorporating exercise into daily routines, individuals can strive for a balance of energy, ensuring that calories in and out are aligned. This alignment determines whether a person can match their total calorie expenditure (TEE) with their daily calorie intake.   The Role of Muscle in Calorie Burning Muscle and Fat: Energy Metabolism Differences Muscle and fat tissues differ in energy metabolism, with muscle being more metabolically active than fat. As a result, even at rest, muscle burns more calories than fat. One pound of fat burns roughly 2 calories per hour, while one pound of muscle burns 6 calories per hour. This discrepancy means that over 24 hours, one pound of muscle can burn around 96 more calories than one pound of fat. This higher energy demand is because muscles are involved in various activities regarding the overall body functioning. Meanwhile, fat and muscle have different densities. So one pound of fat takes up more space in the body than one pound of muscle.   Afterburn Effect and Additional Calorie Burn Muscles also play a role in a phenomenon known as the “afterburn effect,” or excess post-exercise oxygen consumption (EPOC). After exercise, the body continues to consume oxygen at an elevated rate to restore various physiological processes to their pre-exercise state. This recovery period can last from a few minutes to several hours, depending on the intensity and duration of the exercise. During the afterburn effect, muscles require additional energy to repair damaged tissues, replenish depleted glycogen stores (an immediate supply of glucose for muscle cells), remove metabolic byproducts such as lactate (also known as lactic acid, which causes muscle fatigue and soreness when builds up), and restore oxygen levels. The EPOC effect contributes to additional calorie burn (6-15% of an exercise) because the body taps into stored energy sources, primarily fat, to meet the increased metabolic demands during recovery. The higher the intensity and duration of the exercise, the more pronounced the EPOC effect and subsequent calorie burn.   Building Muscle: The Key to Increasing Calorie Burn One way to build muscle is through resistance training, which involves performing exercises against resistance, such as resistance bands. Resistance training not only strengthens existing muscle fibers but also stimulates the growth of new muscle tissue. Another approach to building muscle is through muscle-building exercises specifically targeting muscle hypertrophy. These exercises typically involve higher repetitions and moderate to heavy weights, focusing on specific muscle groups. Examples include squats, lunges, bench presses, and bicep curls. Incorporating these exercises into a comprehensive strength training program helps stimulate muscle growth, boost calorie burn, and improve overall body composition. To engage in resistance training: Start by selecting appropriate exercises that target major muscle groups. Perform 2-3 sets of 8-12 repetitions with a weight that challenges you while maintaining proper form. Gradually increase the weight as you become stronger. For muscle-building exercises, aim for higher repetitions (10-15) and focus on feeling the target muscle group working. Use weights that provide sufficient resistance without sacrificing proper technique. Prioritize rest and recovery to allow muscles to repair and grow stronger.   Muscle Vs. Cardio: Which for Calorie Burning The debate between muscle-focused exercises (strength training) and cardio exercises (aerobic exercises) often arises regarding calorie burning. However, both types of exercise have unique benefits for metabolism and calorie expenditure. Cardio exercises like running, cycling, or swimming are known

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Health

The Neuroscience Behind Meditation

Overview Throughout history, it’s reported that people have been practicing meditation for longer than anticipated, and it has received increasing attention from East to West. Today, more than a powerful tool to pursue conscious living and promote general well-being, the meditative practice using breathing techniques to foster relaxation has captured most attention from neuroscientists for its remarkable impacts on overall cognitive functions, such as memory, attention, cognitive flexibility, and executive function, based on the sole belief that the brain is not hardwired once we reach adulthood, but constantly remains adaptive and open to alterations and adjustments when learning or developing new skills. This discovery has led to further research emphasizing the benefits of meditation on the brain, implying that we can train and exercise our brain to mitigate the aftermath of aging that comes with increasing age. What is the neuroscience behind meditation, and how can we proactively take control of our brain to keep it active and healthy with time? Let’s go over the neuroscience of meditation and explore the potential benefits of meditation for overall cognitive wellness and abilities.   What Does Neuroscience Have to Say About the Impact of Meditation on the Brain? What Is Meditation? The definition of meditation is relatively vague and can vastly vary in different cultures. In simple terms, meditation is a well-known technique that encourages body-mind integration and mental focus with the utilization of deep breathwork or a repetition of a word or phrase. For millennia, in different cultures all around the world, people have used meditation to exercise their brains, engage with their inner thoughts, and refocus their attention. Many believe meditation was originally a cornerstone of spiritual development in many major world religions, such as Buddhism, Christianity, Hinduism, and Islam. Despite the varying techniques, the orientation of meditation in each religious setting was all about tuning in mental awareness, cultivating calmness, and enhancing well-being. Today, the primary purpose of meditation is based on better understanding one’s self and surroundings when enthusiastic meditators are accustomed to the centuries-old practice to harness a sense of relaxation, enhance overall wellness, and gain insight into the meaning of life. Meditation is simple, and anyone can practice it without workout gear or attires needed. The meditative practice has also captured a great deal of attention from the public as effective stress management, with numerous studies praising meditation for its extensive abilities in warding off stress, relieving associated symptoms and discomfort, and resolving conflicts amid hectic lifestyles and schedules. Meditation is divided into nine types of practice, with each affecting the meditator differently depending on their needs and preferences: Mindfulness meditation Spiritual meditation Movement meditation Focused meditation Transcendental meditation Mantra meditation Progressive relaxation Visualization meditation Loving-kindness meditation   What Is Neuroscience? Neuroscience was developed to obtain more knowledge about the human brain. It encompasses the exploration of the brain and the nervous systems, as well as all aspects of the brain’s activities, from formation, development, and structure to functions, malfunctions, and alterations. To map out the brain network, neuroscientists utilize various methodologies to examine and investigate the brain’s overall behaviors and cognitions at a mechanistic level. The brain network, or neural circuits, is responsible for the brain’s diverse functionalities and processes all responses of the human body when activated. The neural network signals different brain regions to carry specific functions after the auditory and conversion of neural messages through the interconnected network of synapses.   Understanding the Brain In addition to being a vital organ, the brain is an incredibly complex system as it houses approximately 80 to 100 trillion neurons despite only accounting for 2-3% of the body weight. These millions and millions of ever-growing brain cells stack and intertwine with others, creating a cell-to-cell communication network. In light of advanced medicine and the more we learn about the brain and its trivial activities, a slew of evidence has confirmed that, unlike other body parts, the brain never stops developing. It means it continues to evolve and adapt to changes or alterations until death, with learning or practicing a new set of skills further proving the brain’s ongoing development into adulthood. Every time we learn new skills, the brain regions accounting for particular activities form new neurons, connections, and patterns from repeated engagements. In other words, our brains become bigger when learning something new, like muscle training. Conversely, the brain is prone to shrinkage over time when we stop exercising our brain, accompanied by other factors like pollutants, substance abuse, and intrinsic aging. This logically explains why the more adults age, the more they are encouraged to keep their brains active with brain-stimulating activities into their golden years, as it is reported that our brains shrink at faster rates than the rates of neuron production as soon as we turn 40, leading to rapid brain decline into the age of 50 and beyond. However, maintaining mental sharpness should be a daily habit that starts as early as possible, regardless of age. There are many ways to promote brain health and protect it from the ultimate consequences of aging, such as getting up and moving, playing brain games, picking up new hobbies or habits, playing instruments, and learning new languages. And meditation is considered one of many activities that could help with brain health and development.   Meditation & the Brain: What Does Neuroscience Say? Before the establishment of neuroscience and neurobiology, the mechanism behind the vital organ remained a lifelong mystery. Therefore, it was mostly, if not completely impossible, to learn more about the effects of meditation on the brain, even though many meditators have sworn by the impressive benefits of meditating on their overall health for decades. In recent years, the benefits of meditation have intrigued neuroscientists, leading to the ongoing rollout of many research studies on the interplay between meditation and the brain. Following these studies producing tremendous outcomes in the last few years, it’s been shown that meditation can provide immeasurable benefits for the brain. What actually happens to the brain

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Diet

Ketogenic Diet, Alternated Weekly With a Normal Diet, Can Increase Healthspan and Memory

Overview The ketogenic diet has been making waves in both the general population and the scientific community in recent years, thanks to its potential benefits for various aspects of health. This dietary approach, commonly called the keto diet, has gained popularity primarily for its association with weight loss and the potential prevention of chronic diseases. However, the diet also faces its fair share of controversy, with critics arguing that increasing fat intake and losing body weight can be achieved simultaneously, casting doubt on the validity of the ketogenic diet as a sustainable and evidence-based eating pattern. Amidst the ongoing debate, it becomes crucial to delve into the latest research surrounding the keto diet and its impact on health to separate fact from fiction. This article provides a comprehensive review of the current scientific knowledge on the ketogenic diet, addressing its pros and cons and shedding light on its possible health outcomes. The article primarily refers to the 2017 Cell Metabolism publication by John C. Newman et al.: Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.   Cyclic Ketogenic Diet Reduces Midlife Mortality and Preserves Memory in Mice Ketogenic Diet: Definition, Mechanisms, and Benefits What Is a Ketogenic Diet? A ketogenic diet is a dietary approach that focuses on triggering a metabolic state called ketosis. In this state, the body shifts from using glucose (derived from carbohydrates) as its primary energy source to burning fat for fuel. A high-fat, low-carbohydrate, and moderate-protein intake characterizes the keto diet. The macronutrient composition of a keto diet consists of 70% fat, 10% carbohydrates, and 20% protein. As a result, the body is prompted to enter ketosis by significantly reducing carbohydrate intake, leading to a shift in metabolic processes.   How Does Ketogenic Diet Work? The low carbohydrate intake in a ketogenic diet restricts the availability of glucose, the preferred energy source for the body. As a result, the body starts breaking down stored fats into molecules called ketones through ketogenesis. Ketones, such as beta-hydroxybutyrate (BHB), serve as an alternative fuel source for various tissues, including the brain. This metabolic adaptation allows the body to utilize stored fat for energy production, leading to weight loss and other health benefits. The controversy is, does increasing fat intake in the ketogenic diet (70%) increase body fat before causing the body to burn stored fat as energy? No, increasing fat intake does not inherently lead to increased body fat. Instead, on a well-formulated ketogenic diet, implemented every other week and not continuously, high fat intake provides satiety, promotes stable blood sugar levels, and helps sustain energy levels. At the same time, the body efficiently burns stored fat for fuel.   Ketogenic Diet Benefits Weight loss: The ketogenic diet has been associated with significant weight loss, primarily due to increased fat-burning and reduced appetite. Improved insulin sensitivity: By limiting carbohydrate intake, the ketogenic diet can help stabilize blood sugar levels and improve insulin sensitivity, benefiting people with diabetes or metabolic syndrome. Enhanced mental clarity and focus: Ketones are an efficient energy source for the brain, which may result in improved cognitive function and mental clarity. Reduced inflammation: Some research suggests that the ketogenic diet may reduce inflammation in the body, which is associated with various chronic diseases. Potential seizure control: The ketogenic diet has been a therapeutic approach for reducing seizures in individuals with epilepsy, particularly children. Potential cardiovascular benefits: A ketogenic diet may improve cardiovascular factors, such as triglyceride levels, blood pressure, and cholesterol. Potential benefits for neurological conditions: The ketogenic diet is under investigation for its potential benefits in various conditions such as Alzheimer’s disease, Parkinson’s disease, and neuronal injury.   Ketogenic Diet: Why Alternate-week and Not Continuous The Continuous Ketogenic Diet Is Obesogenic Research by John C. Newman et al. has shed light on the obesogenic effects of a continuous ketogenic diet and, in turn, discovered the most optimal pattern. Their study involving mice showed that mice fed a ketogenic diet continuously from 12 to 36 months of age experienced a significant increase in body weight, reaching up to 70% higher compared to those fed a standard diet before reaching the 24-month mark. While these continuously ketogenic diet-fed mice eventually reduced their weight to a greater extent than their counterparts on a standard diet before reaching the end of their lifespan at 36 months, they exhibited a greater tendency towards obesity during midlife.     The Continuous Ketogenic Diet Affects Healthspan The study highlighted that mice continuously fed a ketogenic diet displayed a slightly shorter lifespan. Survival rate analysis also revealed a notable decline in health span, with the most significant drop occurring before the mice reached three-quarters of their maximum age. These findings suggest prolonged adherence to a ketogenic diet may adversely affect overall health and longevity.   The Cyclic Ketogenic Diet: A Non-obesogenic Diet In contrast to the continuous ketogenic diet, a cyclic ketogenic diet offers distinct advantages, alternating between periods of ketogenic and standard diet. Mice following a cyclic ketogenic diet maintained similar health characteristics to those on a standard diet, including body weight and lifespan. Moreover, this diet demonstrated additional benefits, such as improved metabolic flexibility and cognitive function. Notably, the cyclic ketogenic diet was non-obesogenic, as it allowed sufficient time for metabolic adaptation and prevented the development of obesity in the mice.   Ketogenic Diet Improves Midlife Survival But Not Lifespan The research findings by John C. Newman et al. suggest that a cyclic ketogenic diet (Cyclic KD; 10% protein and 90% fat; fat content: 24% saturated, 39% monounsaturated, and 37% polyunsaturated) improves midlife survival. However, it does not extend the overall lifespan compared to a control (10% protein, 13% fat, and 77% carbohydrates) diet. Mice on Cyclic KD showed similar body weight to the control group, while mice on a cyclic high-fat diet (Cyclic HF; 10% protein, 75% fat, 15% carbohydrates) were slightly heavier. Caloric intake was higher during KD or HF diet weeks and lower during control diet weeks for both groups. Cyclic KD and

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